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One-Pot Template-Free Synthesis of NaYF4 Upconversion Hollow Nanospheres for Bioimaging and Drug Delivery

Authors

  • Dr. Gan Tian,

    1. CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049 (P.R. China)
    2. College of Chemistry, Sichuan University, Chengdu, 610064 (P.R. China)
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    • These authors contributed equally.

  • Dr. Longsheng Duan,

    1. CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049 (P.R. China)
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    • These authors contributed equally.

  • Dr. Xiao Zhang,

    1. CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049 (P.R. China)
    2. National Center for Nanosciences and Technology of China, Beijing, 100190 (P.R. China)
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  • Dr. Wenyan Yin,

    Corresponding author
    1. CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049 (P.R. China)
    • CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049 (P.R. China)===

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  • Dr. Liang Yan,

    1. CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049 (P.R. China)
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  • Dr. Liangjun Zhou,

    1. CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049 (P.R. China)
    2. College of Materials Science and Opto-electronic Technology, Graduate University of Chinese Academy of Sciences, Beijing 100049 (P.R. China)
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  • Dr. Xiaodong Liu,

    1. CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049 (P.R. China)
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  • Dr. Xiaopeng Zheng,

    1. CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049 (P.R. China)
    2. College of Materials Science and Opto-electronic Technology, Graduate University of Chinese Academy of Sciences, Beijing 100049 (P.R. China)
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  • Dr. Jinxia Li,

    1. CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049 (P.R. China)
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  • Dr. Zhanjun Gu,

    Corresponding author
    1. CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049 (P.R. China)
    • CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049 (P.R. China)===

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  • Prof. Yuliang Zhao

    Corresponding author
    1. CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049 (P.R. China)
    2. National Center for Nanosciences and Technology of China, Beijing, 100190 (P.R. China)
    3. College of Chemistry, Sichuan University, Chengdu, 610064 (P.R. China)
    • CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049 (P.R. China)===

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Abstract

Hollow-structured nanomaterials with fluorescent properties are extremely attractive for image-guided cancer therapy. In this paper, sub-100 nm and hydrophilic NaYF4 upconversion (UC) hollow nanospheres (HNSs) with multicolor UC luminescence and drug-delivery properties were successfully prepared by a facile one-pot template-free hydrothermal route using polyetherimide (PEI) polymer as the stabilizing agent. XRD, SEM, TEM, and N2-adsorption/desorption were used to characterize the as-obtained products. The growth mechanism of the HNSs has been systematically investigated on the basis of the Ostwald ripening. Under 980 nm excitation, UC emissions of HNSs can be tuned by a simple change of the concentration or combination of various upconverters. As a result, the PEI-coated HNSs could be used as efficient probes for in vitro upconversion luminescence (UCL) cell imaging. Furthermore, a doxorubicin storage/release behavior and cancer-cell-killing ability investigation reveal that the product has the potential to be a drug carrier for cancer therapy.

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