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Synthesis of 1-Difluoroalkylated Isoquinolines via Palladium-Catalyzed Radical Cascade Difluoroalkylation-Cyclization of Vinyl Isocyanides with Bromodifluoroacetic Derivatives

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Abstract

A general method for the synthesis of 1-difluoroalkyl isoquinolines through a palladium-catalyzed radical cascade difluoroalkylation-cyclization of vinyl isocyanides with bromodifluoroacetic derivants is described.The difluoroalkylation-cyclization products can also be readily converted to more valuable gem-difluorocontaining compounds.

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