Substituent Effects in BODIPY in Live Cell Imaging (pages 3598–3605)
Dr. Sandip V. Mulay, Tesla Yudhistira, Dr. Minsuk Choi, Youngsam Kim, Jinjoo Kim, Yoon Jeong Jang, Prof. Dr. Sangyong Jon and Prof. Dr. David G. Churchill
Version of Record online: 23 NOV 2016 | DOI: 10.1002/asia.201601400
Body? Pie? No, it′s BODIPY! Substituents on boron-dipyrromethene (BODIPY) have been shown to play significant roles for the detection of biologically important analytes under in vitro conditions and in live cell imaging studies. The probe shows a selective and sensitive turn-on response with NaOCl over other reactive oxygen/nitrogen species (ROS/RNS) in vitro. Surprisingly, in live cell experiments, the probe specifically accumulates in lipid droplets and shows fluorescence turn-on responses because of aggregation-induced emission (AIE) owing to the lipophilic mesityl group at the meso position of the BODIPY.