Chemistry – An Asian Journal

Cover image for Vol. 1 Issue 6

December 18, 2006

Volume 1, Issue 6

Pages 757–917

  1. Cover Picture

    1. Top of page
    2. Cover Picture
    3. Graphical Abstract
    4. Focus Review
    5. Full Papers
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    1. Cover Picture: A Method of Orthogonal Oligosaccharide Synthesis Leading to a Combinatorial Library Based on Stationary Solid-Phase Reaction (Chem. Asian J. 6/2006) (page 757)

      Takuro Ako, Shusaku Daikoku, Isao Ohtsuka, Rumiko Kato and Osamu Kanie

      Article first published online: 7 DEC 2006 | DOI: 10.1002/asia.200690013

      Libraries not of books but of oligosaccharides have potentially important applications in medicine and the pharmaceutical industry. However, the building of these libraries is hindered by lengthy protocols and specific reaction conditions that cannot be applied generally. In response to these issues, Kanie and co-workers developed an efficient synthetic strategy based on a combination of solid-phase reaction and orthogonal glycosylation, in which monosaccharides are coupled to each other step by step to form anomeric combinations of oligosaccharides. Find out more in their Full Paper on page 798 ff.

  2. Graphical Abstract

    1. Top of page
    2. Cover Picture
    3. Graphical Abstract
    4. Focus Review
    5. Full Papers
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  3. Focus Review

    1. Top of page
    2. Cover Picture
    3. Graphical Abstract
    4. Focus Review
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    1. Shape-Persistent Aromatic Amide Oligomers: New Tools for Supramolecular Chemistry (pages 766–778)

      Zhan-Ting Li, Jun-Li Hou, Chuang Li and Hui-Ping Yi

      Article first published online: 2 NOV 2006 | DOI: 10.1002/asia.200600186

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      Multipurpose molecular origami: Folding or helical oligomers have been assembled to mimic biological helical structures. Aromatic amide foldamers driven by hydrogen bonding are one family of such compounds. These foldamers have found increasing application in cyclization promotion, molecular recognition and self-assembly, and reaction acceleration, to name a few.

  4. Full Papers

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    1. Asymmetric Resolution in Ester Reduction by NaBH4 at the Interface of Aqueous Aggregates of Amino Acid, Peptide, and Chiral-Counterion-Based Cationic Surfactants (pages 780–788)

      Antara Dasgupta, Rajendra Narayan Mitra, Sangita Roy and Prasanta Kumar Das

      Article first published online: 10 NOV 2006 | DOI: 10.1002/asia.200600206

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      Optically active soap: Asymmetric resolution in ester reduction by NaBH4 can be obtained at the interface of aqueous chiral cationic aggregates through a simple and environmentally benign pathway. This method is correlated with the induced supramolecular chirality generated from the varied spatial asymmetry and steric constraint of the chiral amphiphiles.

    2. Photo-Cross-Linked Small-Molecule Microarrays as Chemical Genomic Tools for Dissecting Protein–Ligand Interactions (pages 789–797)

      Naoki Kanoh, Aya Asami, Makoto Kawatani, Kaori Honda, Saori Kumashiro, Hiroshi Takayama, Siro Simizu, Tomoyuki Amemiya, Yasumitsu Kondoh, Satoru Hatakeyama, Keiko Tsuganezawa, Rei Utata, Akiko Tanaka, Shigeyuki Yokoyama, Hideo Tashiro and Hiroyuki Osada

      Article first published online: 30 OCT 2006 | DOI: 10.1002/asia.200600208

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      Not fussy is good: A nonselective photo-cross-linking approach can be applied to introduce a variety of small molecules onto glass slides in a functional-group-independent manner. The resulting photo-cross-linked small-molecule microarray is useful not merely for ligand screening but also for studies on structure–activity relationships.

    3. A Method of Orthogonal Oligosaccharide Synthesis Leading to a Combinatorial Library Based on Stationary Solid-Phase Reaction (pages 798–813)

      Takuro Ako, Shusaku Daikoku, Isao Ohtsuka, Rumiko Kato and Osamu Kanie

      Article first published online: 22 NOV 2006 | DOI: 10.1002/asia.200600210

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      Library building: A general method of synthesizing combinatorial trisaccharide libraries is disclosed. An efficient synthesis of a trisaccharide library consisting of anomers with the L-fucosyl-(1[RIGHTWARDS ARROW]6)-D-galactosyl-(1[RIGHTWARDS ARROW]2/3/4/6)-D- glucose sequence was performed based on orthogonal glycosylation and stationary solid-phase reaction.

    4. Thermotropic Liquid Crystals Based on Extended 2,5-Disubstituted-1,3,4-Oxadiazoles: Structure–Property Relationships, Variable-Temperature Powder X-ray Diffraction, and Small-Angle X-ray Scattering Studies (pages 814–825)

      Jie Han, Stephen Sin-Yin Chui and Chi-Ming Che

      Article first published online: 10 NOV 2006 | DOI: 10.1002/asia.200600252

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      The faces of phases: The liquid-crystal properties of extended 2,5-disubstituted-1,3,4-oxadiazoles are strongly affected by the terminal substituents, mesogenic core length, and crystal packing. Distinctive molecular-packing arrangements of these mesogenic materials are determined by restrained Rietveld refinement of powder X-ray diffraction data.

    5. Effect of Lithia and Substrate on the Electrochemical Performance of a Lithia/Cobalt Oxide Composite Thin-Film Anode (pages 826–831)

      Yan Yu, Yi Shi and Chun-Hua Chen

      Article first published online: 13 NOV 2006 | DOI: 10.1002/asia.200600157

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      Recharge your batteries: Highly porous reticular Li2O/CoO composite thin-film anodes show initial coulombic efficiencies and capacities that are dependent on Li2O content and specific surface area. The capacities are also temperature-sensitive and can be further increased by voltage cycling at high temperature.

    6. Halide-Anion Binding by Singly and Doubly N-Confused Porphyrins (pages 832–844)

      Hiromitsu Maeda, Tatsuki Morimoto, Atsuhiro Osuka and Hiroyuki Furuta

      Article first published online: 8 NOV 2006 | DOI: 10.1002/asia.200600182

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      Confused and in a bind: C6F5-substituted N-confused porphyrins (NCPs) bind halide anions tightly at the peripheral NH moieties through hydrogen bonding. The orientation and magnitude of the dipole moments are important in the differentiation of the affinity of NCPs for anions.

    7. Enantio- and Diastereoselective Total Synthesis of (+)-Panepophenanthrin, a Ubiquitin-Activating Enzyme Inhibitor, and Biological Properties of Its New Derivatives (pages 845–851)

      Masayoshi Matsuzawa, Hideaki Kakeya, Junichiro Yamaguchi, Mitsuru Shoji, Rie Onose, Hiroyuki Osada and Yujiro Hayashi

      Article first published online: 14 NOV 2006 | DOI: 10.1002/asia.200600199

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      A key step in the asymmetric total synthesis of (+)-panepophenanthrin (3), an inhibitor of ubiquitin-activating enzyme (E1), is the catalytic asymmetric α aminoxylation of 1,4-cyclohexanedione monoethylene ketal (1) to give α-aminoxy ketone 2, followed by several diastereoselective reactions. The investigation of the biological properties of new derivatives of 3 allowed the development of new cell-permeable E1 inhibitors.

    8. Origin of the π-Facial Stereoselectivity in the Addition of Nucleophilic Reagents to Chiral Aliphatic Ketones as Evidenced by High-Level Ab Initio Molecular-Orbital Calculations (pages 852–859)

      Osamu Takahashi, Katsuyoshi Yamasaki, Yuji Kohno, Kazuyoshi Ueda, Hiroko Suezawa and Motohiro Nishio

      Article first published online: 23 NOV 2006 | DOI: 10.1002/asia.200600204

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      Strength in weakness: C[BOND]H⋅⋅⋅π and C[BOND]H⋅⋅⋅O hydrogen bonds are important in controlling the conformation of alkyl 1-cyclohexylethyl ketones. The ratio of the diastereomeric alcohols produced in the nucleophilic addition to these compounds can therefore be accurately calculated on the basis of the conformer distribution.

    9. Self-Assembled Aggregates and Molecular Bilayer Films of a Double-Chain Fullerene Lipid: Structure and Electrochemistry (pages 860–867)

      Hiroto Murakami, Takashi Nakanishi, Makoto Morita, Naoya Taniguchi and Naotoshi Nakashima

      Article first published online: 31 OCT 2006 | DOI: 10.1002/asia.200600229

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      Organic balls: Double- and triple-chain fullerene lipids form spherical aggregates in alcohols. Cast films of one example form molecular bilayers that undergo a phase transition, and their electrochemistry shows a strong dependence on temperature.

    10. Rhodium-Catalyzed Cascade Reaction of 1,6-Enynes Involving Addition, Cyclization, and β-Oxygen Elimination (pages 868–877)

      Tomoya Miura, Masahiko Shimada and Masahiro Murakami

      Article first published online: 13 NOV 2006 | DOI: 10.1002/asia.200600254

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      Rh-ide the waterfall: Rhodium(I) complexes catalyze cascade reactions of 1,6-enynes with arylboronic acids or methylmagnesium chloride to produce cyclopentanes that contain a tetrasubstituted exo olefin and a pendant vinyl group. The reaction regenerates the catalytically active RhI–OR species by β-oxygen elimination of rhodium.

    11. Titanium and Zirconium Complexes with Non-Salicylaldimine-Type Imine–Phenoxy Chelate Ligands: Syntheses, Structures, and Ethylene-Polymerization Behavior (pages 878–887)

      Yasuhiko Suzuki, Hidetsugu Tanaka, Toshiyuki Oshiki, Kazuhiko Takai and Terunori Fujita

      Article first published online: 20 NOV 2006 | DOI: 10.1002/asia.200600256

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      Let's see who's fastest: New Ti and Zr complexes that bear imine–phenoxy chelate ligands can be synthesized and used as precatalysts for ethylene polymerization. The catalytic activity of the titanium complexes are further improved by employing [Ph3C]+[B(C6F5)4]/AliBu3 or methylaluminoxane as cocatalyst.

    12. Shape-Dependent Catalytic Activity of Silver Nanoparticles for the Oxidation of Styrene (pages 888–893)

      Run Xu, Dingsheng Wang, Jiatao Zhang and Yadong Li

      Article first published online: 20 NOV 2006 | DOI: 10.1002/asia.200600260

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      The shape of things to come: The effect of the shape of different types of silver nanoparticles on the rate of oxidation of styrene was studied. The nanocubes had the {100} crystal faces as the basal plane, whereas the truncated triangular and near-spherical nanoparticles exposed mainly the most-stable {111} crystal faces. Hence the reaction rate over the nanocubes was more than 14 and 4 times higher than over nanoplates and near-spherical nanoparticles, respectively.

    13. Synthesis of Murisolin, (15R, 16R, 19R, 20S)-Murisolin A, and (15R, 16R, 19S, 20S)-16,19-cis-Murisolin and Their Inhibitory Action with Bovine Heart Mitochondrial Complex I (pages 894–904)

      Yasunao Hattori , Yuka Kimura, Aki Moroda, Hiroyuki Konno, Masato Abe, Hideto Miyoshi, Tetsuhisa Goto  and Hidefumi Makabe

      Article first published online: 8 NOV 2006 | DOI: 10.1002/asia.200600261

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      Not just from tropical fruit: Epoxy alcohol 4 can be used as a versatile chiral building block for synthesizing the stereoisomers of mono-THF annonaceous acetogenins such as murisolin (1), (15R, 16R, 19R, 20S)-murisolin A, and (15R, 16R, 19S, 20S)-16,19-cis-murisolin. The inhibitory activity of these murisolin compounds was examined with bovine heart mitochondrial complex I.

  5. Preview

    1. Top of page
    2. Cover Picture
    3. Graphical Abstract
    4. Focus Review
    5. Full Papers
    6. Preview
    1. You have free access to this content
      Preview: Chem. Asian J. 1/2007 (page 917)

      Article first published online: 7 DEC 2006 | DOI: 10.1002/asia.200690015

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