Photo-Cross-Linked Small-Molecule Microarrays as Chemical Genomic Tools for Dissecting Protein–Ligand Interactions (pages 789–797)
Naoki Kanoh, Aya Asami, Makoto Kawatani, Kaori Honda, Saori Kumashiro, Hiroshi Takayama, Siro Simizu, Tomoyuki Amemiya, Yasumitsu Kondoh, Satoru Hatakeyama, Keiko Tsuganezawa, Rei Utata, Akiko Tanaka, Shigeyuki Yokoyama, Hideo Tashiro and Hiroyuki Osada
Article first published online: 30 OCT 2006 | DOI: 10.1002/asia.200600208
Not fussy is good: A nonselective photo-cross-linking approach can be applied to introduce a variety of small molecules onto glass slides in a functional-group-independent manner. The resulting photo-cross-linked small-molecule microarray is useful not merely for ligand screening but also for studies on structure–activity relationships.