Pyridyl-Substituted Corrole Isomers: Synthesis and their Regulation to G-quadruplex Structures (pages 114–122)
Heng Ma, Ming Zhang, Dan Zhang, Rong Huang, Yang Zhao, Hao Yang, Yijing Liu, Xiaocheng Weng, Yangyang Zhou, Minggang Deng, Liang Xu and Xiang Zhou
Article first published online: 24 NOV 2009 | DOI: 10.1002/asia.200900270
Act and interact: Surface plasmon resonance (SPR) is used to compare the interactions of five cationic methylpyridylium corroles with different types of G-quadruplexes such as cmyc, htelo, and bcl2. The analysis shows a high selectivity of the G-quadruplexes to double-stranded DNA. These interactions are investigated with CD, Tm, PCR-stop (PCR=polymerase chain reaction), and polymerase-stop assays.