Small Mesoporous Silica Nanoparticles as Carriers for Enhanced Photodynamic Therapy (pages 2332–2338)
Jie Zhu, Huixiang Wang, Lei Liao, Lingzhi Zhao, Liang Zhou, Meihua Yu, Prof. Yunhua Wang, Prof. Baohong Liu and Prof. Chengzhong Yu
Version of Record online: 8 JUL 2011 | DOI: 10.1002/asia.201100064
Small mesoporous silica nanoparticles (diameters ca. 37 nm) have a high loading capacity for a hydrophobic photosensitizer, SiPcCl2, and excellent endocytosis property. Thus, the amount of SiPcCl2 delivered to cancer cells increased by approximately two orders of magnitude compared to pure SiPcCl2, and the photodynamic therapy (PDT) efficiency was enhanced by over fourfold.