This work was supported by K08 MH074967-01 from NIMH and a BIRCWH award, (K12 HD051958), to Marjorie Solomon. Statistical support was made possible by UL1 RR024246 from the National Center for Research Resources, a component of the NIH and NIH Roadmap for Medical Research. The authors report no conflicts of interest.
Oxytocin and Vasopressin in Children and Adolescents With Autism Spectrum Disorders: Sex Differences and Associations With Symptoms
Article first published online: 14 FEB 2013
© 2013 International Society for Autism Research, Wiley Periodicals, Inc.
Volume 6, Issue 2, pages 91–102, April 2013
How to Cite
Miller, M., Bales, K. L., Taylor, S. L., Yoon, J., Hostetler, C. M., Carter, C. S. and Solomon, M. (2013), Oxytocin and Vasopressin in Children and Adolescents With Autism Spectrum Disorders: Sex Differences and Associations With Symptoms. Autism Res, 6: 91–102. doi: 10.1002/aur.1270
- Issue published online: 23 APR 2013
- Article first published online: 14 FEB 2013
- Manuscript Accepted: 4 DEC 2012
- Manuscript Received: 11 MAY 2012
- NIMH. Grant Number: K08 MH074967-01
- BIRCWH award. Grant Number: K12 HD051958
- National Center for Research Resources. Grant Number: UL1 RR024246
- sex differences;
- repetitive behaviors;
There has been intensified interest in the neuropeptides oxytocin (OT) and arginine vasopressin (AVP) in autism spectrum disorders (ASD) given their role in affiliative and social behavior in animals, positive results of treatment studies using OT, and findings that genetic polymorphisms in the AVP–OT pathway are present in individuals with ASD. Nearly all such studies in humans have focused only on males. With this preliminary study, we provide basic and novel information on the involvement of OT and AVP in autism, with an investigation of blood plasma levels of these neuropeptides in 75 preadolescent and adolescent girls and boys ages 8–18: 40 with high-functioning ASD (19 girls, 21 boys) and 35 typically developing children (16 girls, 19 boys). We related neuropeptide levels to social, language, repetitive behavior, and internalizing symptom measures in these individuals. There were significant gender effects: Girls showed higher levels of OT, while boys had significantly higher levels of AVP. There were no significant effects of diagnosis on OT or AVP. Higher OT values were associated with greater anxiety in all girls, and with better pragmatic language in all boys and girls. AVP levels were positively associated with restricted and repetitive behaviors in girls with ASD but negatively (nonsignificantly) associated with these behaviors in boys with ASD. Our results challenge the prevailing view that plasma OT levels are lower in individuals with ASD, and suggest that there are distinct and sexually dimorphic mechanisms of action for OT and AVP underlying anxiety and repetitive behaviors. Autism Res 2013, 6: 91–102. © 2013 International Society for Autism Research, Wiley Periodicals, Inc.