Investigation of Maternal Genotype Effects in Autism by Genome-Wide Association
Version of Record online: 25 FEB 2014
© 2014 International Society for Autism Research, Wiley Periodicals, Inc.
Volume 7, Issue 2, pages 245–253, April 2014
How to Cite
Yuan, H. and Dougherty, J. D. (2014), Investigation of Maternal Genotype Effects in Autism by Genome-Wide Association. Autism Res, 7: 245–253. doi: 10.1002/aur.1363
- Issue online: 15 APR 2014
- Version of Record online: 25 FEB 2014
- Manuscript Accepted: 18 JAN 2014
- Manuscript Received: 17 MAY 2013
- Mallinkrodt Foundation
- National Institutes of Health (NIH). Grant Numbers: 4R00NS067239 -03, 9R01MH100027-06
- Autism Genetic Resource Exchange (AGRE) Consortium*
- National Institute of Mental Health. Grant Number: 1U24MH081810
- NIH Genes, Environment and Health Initiative (GEI). Grant Numbers: U01 HG004422, U01HG004438
- GENEVA Coordinating Center. Grant Number: U01 HG004446
- Collaborative Study on the Genetics of Alcoholism. Grant Number: U10 AA008401
- Collaborative Genetic Study of Nicotine Dependence. Grant Number: P01 CA089392
- Family Study of Cocaine Dependence. Grant Number: R01 DA013423
Table S1. P-values of top hits after combining discovery and replicate stages. Only single-nucleotide polymorphisms (SNPs) that had their significance level raised after merging were included in this table. For each SNP, we included P-values of case mother versus father test in discovery stage (AGREMvF), case mother versus control female test in discovery stage (AGREFvF), case mother versus father test in replicate stage (simonMvF), case mother versus control female test in replicate stage (simonFvF), case mother versus father test in merged dataset (mergeMvF), and case mother versus control female test in merged dataset (mergeFvF).
Table S2. Comparison of significant levels between our study and EMIM result for top 10 hits. We tested the 10 most significant single-nucleotide polymorphisms (SNPs) in Table 1 and used Cordell's linear model (EMIM) to predict their association with autism under child genotype effect model, maternal genotype effect model, and maternal imprinting model, respectively. For SNPs that are not directly genotyped, we looked for genotyped SNPs in LD (R2 > 0.9), with target SNPs and performed EMIM on them. P-values for each SNP under each model is reported in the table. pvaluesCG represents P-values under child genotype effect model; pvaluesMG represents P-values under maternal genotype model; and pvaluesIM represents P-values under maternal imprinting model. NA,no SNP in LD available for testing.
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