Autism spectrum disorders are associated with an elevated autoantibody response to tissue transglutaminase-2
Version of Record online: 19 APR 2011
Copyright © 2011, International Society for Autism Research, Wiley-Liss, Inc.
Volume 4, Issue 4, pages 242–249, August 2011
How to Cite
Rosenspire, A., Yoo, W., Menard, S. and Torres, A. R. (2011), Autism spectrum disorders are associated with an elevated autoantibody response to tissue transglutaminase-2. Autism Res, 4: 242–249. doi: 10.1002/aur.194
- Issue online: 5 AUG 2011
- Version of Record online: 19 APR 2011
- Manuscript Accepted: 13 MAR 2011
- Manuscript Received: 3 SEP 2010
- Cure Autism Now Foundation (which has merged with Autism Speaks)
- Autism Genetic Resource Exchange (AGRE)
- National Institute of Mental Health. Grant Number: 1U24MH081810
- anti-transglutaminase antibody;
We report that a significant number of autistic children have serum levels of IgA antibodies above normal to the enzyme tissue transglutaminase II (TG2), and that expression of these antibodies to TG2 is linked to the (HLA)-DR3, DQ2 and DR7, DQ2 haplotypes. TG2 is expressed in the brain, where it has been shown to be important in cell adhesion and synaptic stabilization. Thus, these children appear to constitute a subpopulation of autistic children who fall within the autism disease spectrum, and for whom autoimmunity may represent a significant etiological component of their autism. Autism Res2011,4:242–249. © 2011 International Society for Autism Research, Wiley Periodicals, Inc.