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Autism spectrum disorders are associated with an elevated autoantibody response to tissue transglutaminase-2

Authors

  • Allen Rosenspire,

    Corresponding author
    1. Department of Immunology and Microbiology, Wayne State University School of Medicine, Detroit, Michigan
    • Wayne State University School of Medicine, Room 221 Lande Medical Research Building, 550 E. Canfield Street, Detroit, MI 48201
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  • Wonsuk Yoo,

    1. Department of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan
    Current affiliation:
    1. Biostatistics and Epidemiology Division, University of Tennessee Health Science Center, 66 North Pauline Street, Suite 633, Memphis, TN 38163
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  • Sherri Menard,

    1. Department of Immunology and Microbiology, Wayne State University School of Medicine, Detroit, Michigan
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  • Anthony R. Torres

    1. Centers for Persons with Disabilities, Utah State University, Logan, Utah
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Abstract

We report that a significant number of autistic children have serum levels of IgA antibodies above normal to the enzyme tissue transglutaminase II (TG2), and that expression of these antibodies to TG2 is linked to the (HLA)-DR3, DQ2 and DR7, DQ2 haplotypes. TG2 is expressed in the brain, where it has been shown to be important in cell adhesion and synaptic stabilization. Thus, these children appear to constitute a subpopulation of autistic children who fall within the autism disease spectrum, and for whom autoimmunity may represent a significant etiological component of their autism. Autism Res2011,4:242–249. © 2011 International Society for Autism Research, Wiley Periodicals, Inc.

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