Autism and cancer risk
Article first published online: 5 AUG 2011
Copyright © 2011, International Society for Autism Research, Wiley Periodicals, Inc.
Volume 4, Issue 4, pages 302–310, August 2011
How to Cite
Crespi, B. (2011), Autism and cancer risk. Autism Res, 4: 302–310. doi: 10.1002/aur.208
- Issue published online: 5 AUG 2011
- Article first published online: 5 AUG 2011
- Manuscript Accepted: 31 MAY 2011
- Manuscript Received: 11 JUN 2010
A literature review was conducted on the genetic and developmental bases of autism in relation to genes and pathways associated with cancer risk. Convergent lines of evidence from four types of analysis: (1) recent theoretical studies on the causes of autism, (2) epidemiological studies, (3) genetic analyses linking autism with mutations in tumor suppressor genes and other cancer-associated genes and pathways, and (4) contrasts with schizophrenia, Parkinson's, and Alzheimer's disease indicate that autism may involve altered cancer risk. This evidence should motivate further epidemiological studies, and it provides useful insights into the nature of the genetic, epigenetic, and environmental factors underlying the etiologies of autism, other neurological conditions, and carcinogenesis. Autism Res2011,4:302–310. © 2011 International Society for Autism Research, Wiley Periodicals, Inc.