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Protective effects of enalapril, an angiotensin-converting enzyme inhibitor, on multiple organ damage following scald injury in rats

Authors

  • Bing-Qian Zhang,

    1. Institute of Burn Research of PLA, National Key Laboratory of Trauma, Burn and Combined Injury, Third Military Medical University, Chongqing, People's Republic of China
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  • Guang Wang,

    1. Institute of Burn Research of PLA, National Key Laboratory of Trauma, Burn and Combined Injury, Third Military Medical University, Chongqing, People's Republic of China
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  • Jia-Ping Zhang,

    1. Institute of Burn Research of PLA, National Key Laboratory of Trauma, Burn and Combined Injury, Third Military Medical University, Chongqing, People's Republic of China
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  • Jiong-Yu Hu,

    1. Institute of Burn Research of PLA, National Key Laboratory of Trauma, Burn and Combined Injury, Third Military Medical University, Chongqing, People's Republic of China
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  • Rong Xiao,

    1. Institute of Burn Research of PLA, National Key Laboratory of Trauma, Burn and Combined Injury, Third Military Medical University, Chongqing, People's Republic of China
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  • Ze-Yuan Lei,

    1. Institute of Burn Research of PLA, National Key Laboratory of Trauma, Burn and Combined Injury, Third Military Medical University, Chongqing, People's Republic of China
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  • Jing Ruan,

    1. Institute of Burn Research of PLA, National Key Laboratory of Trauma, Burn and Combined Injury, Third Military Medical University, Chongqing, People's Republic of China
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  • Yong-Ming Dang,

    1. Institute of Burn Research of PLA, National Key Laboratory of Trauma, Burn and Combined Injury, Third Military Medical University, Chongqing, People's Republic of China
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  • Dong-Xia Zhang,

    1. Institute of Burn Research of PLA, National Key Laboratory of Trauma, Burn and Combined Injury, Third Military Medical University, Chongqing, People's Republic of China
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  • Xiu-Wu Bian,

    Corresponding author
    1. Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University, Chongqing, People's Republic of China
    • Institute of Burn Research of PLA, National Key Laboratory of Trauma, Burn and Combined Injury, Third Military Medical University, Chongqing, People's Republic of China. Tel.: +86 23 65461696; Fax: +86 23 65461696
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  • Yue-Sheng Huang

    Corresponding author
    1. Institute of Burn Research of PLA, National Key Laboratory of Trauma, Burn and Combined Injury, Third Military Medical University, Chongqing, People's Republic of China
    • Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University, Chongqing, People's Republic of China
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Abstract

The aim of this study is to investigate the effects of enalapril, an angiotensin-converting enzyme inhibitor, on multiple organ damage after scald injury. Healthy adult rats (half male and half female; 8–12 weeks old) were randomly assigned to the following treatments: sham operation, scald injury, and intraperitoneal enalapril (1, 2, and 4 mg/kg body weight) treatment after scalding. At 1, 12, and 24 H postscald, left ventricular and aortic hemodynamics were measured using a multichannel physiological recorder. Functional and pathological changes of the heart, liver, and kidney were examined by biochemical and histological methods. Compared with sham controls, untreated scalded animals showed decreased hemodynamic parameters and increased myocardial angiotensin II, serum creatine kinase heart isoenzyme, and serum cardiac troponin I and histopathological inflammation in the myocardium 12 H postscald. These hemodynamic, functional, and pathological changes were attenuated by 1 mg/kg enalapril. Enalapril reversed scald-induced elevations in aspartate aminotransferase, alanine aminotransferase, blood urea nitrogen, and blood creatinine 12 H postscald, and ameliorated focal necrosis in the liver and erythrocyte cast formation in renal tubules. However, higher doses of enalapril yielded less or no improvement in organ dysfunction. Enalapril at 1 mg/kg attenuates scald-induced multiple organ damage in rats.

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