Original Paper
You have free access to this content
Prevalence of desloratadine poor metabolizer phenotype in healthy Jordanian males
Article first published online: 5 FEB 2012
DOI: 10.1002/bdd.1770
Copyright © 2012 John Wiley & Sons, Ltd.
Additional Information
How to Cite
Hakooz, N. and Salem, I. I. (2012), Prevalence of desloratadine poor metabolizer phenotype in healthy Jordanian males. Biopharm. Drug Dispos., 33: 15–21. doi: 10.1002/bdd.1770
Publication History
- Issue published online: 7 MAR 2012
- Article first published online: 5 FEB 2012
- Accepted manuscript online: 23 JAN 2012 06:20AM EST
- Manuscript Accepted: 7 JAN 2012
- Manuscript Revised: 28 DEC 2011
- Manuscript Received: 1 NOV 2011
References
- 1, . Desloratadine: A new, nonsedating, oral antihistamine. J Allergy Clin Immunol 2001; 107: 751–762.
- 2, , , et al. Biochemical characterization of desloratadine, a potent antagonist of the human histamine H(1) receptor. Eur J Pharmacol 2002; 449: 229–237.
- 3, . Safety and efficacy of desloratadine in subjects with seasonal allergic rhinitis or chronic urticaria: results of four postmarketing surveillance studies. Clin Drug Investig 2010; 30: 109–122.
- 4. Urticaria and its subtypes: The role of second-generation antihistamines. Eur J Intern Med 2012; 23: 26–30.
- 5, , , et al. Desloratadine demonstrates dose proportionality in healthy adults after single doses. Clin Pharmacokinet 2002; 41 (Suppl 1): 1–6.
- 6, , , et al. Disposition of desloratadine in healthy volunteers. Xenobiotica 2007; 37: 770–787.
- 7, , , et al. Adult and paediatric poor metabolisers of desloratadine: an assessment of pharmacokinetics and safety. Expert Opin Drug Saf 2006; 5: 211–223.
- 8, , , et al. Effect of race and sex on single and multiple dose pharmacokinetics of desloratadine. Clin Pharmacokinet 2002; 41 (Suppl 1): 21–28.
- 9, , , , , . Oral bioavailability of desloratadine is unaffected by food. Clin Pharmacokinet 2002; 41(Suppl 1): 7–12.
- 10. Desloratadine for chronic idiopathic urticaria: a review of clinical efficacy. Am J Clin Dermatol 2007; 8: 271–283.
- 11, , , , . Desloratadine has no clinically relevant electrocardiographic or pharmacodynamic interactions with ketoconazole. Clin Pharmacokinet 2002; 41(Suppl 1): 37–44.
- 12, , , , . Grapefruit juice reduces the oral bioavailability of fexofenadine but not desloratadine. Clin Pharmacokinet 2002; 41: 311–318.
- 13, , , , , . Lack of clinically relevant interaction between desloratadine and erythromycin. Clin Pharmacokinet 2002; 41(Suppl 1): 29–35.
- 14, , , et al. Identification of human UDP-glucuronosyltransferase enzyme(s) responsible for the glucuronidation of 3-hydroxydesloratadine. Biopharm Drug Dispos 2004; 25: 243–252.Direct Link:
- 15, , . Comparison of pharmacokinetics and metabolism of desloratadine, fexofenadine, levocetirizine and mizolastine in humans. Fundam Clin Pharmacol 2004; 18: 399–411.Direct Link:
- 16, , , . In vitro characterization of the inhibition profile of loratadine, desloratadine, and 3-OH-desloratadine for five human cytochrome P-450 enzymes. Drug Metab Dispos 2001; 29: 1173–1175.
- 17, , , , . Molecular analysis of HLA allelic frequencies and haplotypes in Jordanians and comparison with other related populations. Hum Immunol 2001; 62: 901–909.
- 18Guidance For Industry: Bioanalytical Method Validation for Human Studies. FDA: USA, 2001.
- 19, , , . A pharmacokinetic profile of desloratadine in healthy adults, including elderly. Clin Pharmacokinet 2002; 41(Suppl 1): 13–19.
- 20. The safety and efficacy of desloratadine for the management of allergic disease. Drug Saf 2005; 28: 1101–1118.

1099-081X/asset/BDD_left.gif?v=1&s=c11e8078e868403f8ca4b2a7b9807faafa9d1c98)
1099-081X/asset/BDD_right.gif?v=1&s=7deb44a49db3df64c5f6356bcbf8e918ac003681)
