Original Paper

Contribution of specific binding to the central benzodiazepine site to the brain concentrations of two novel benzodiazepine site ligands

  1. Andrew Pike1,†,*,
  2. Susan M. Cook2,
  3. Alan P. Watt1,
  4. Paul Scott-Stevens1,
  5. Thomas W. Rosahl3,
  6. Ruth M. McKernan3,
  7. Luanda J. Pym2,
  8. Alec Guiblin1,
  9. Christopher Moyes1,
  10. Bindi Sohal1,
  11. John R. Atack2

Article first published online: 14 JUN 2007

DOI: 10.1002/bdd.553

Issue

Biopharmaceutics & Drug Disposition

Biopharmaceutics & Drug Disposition

Volume 28, Issue 6, pages 275–282, September 2007

Additional Information

How to Cite

Pike, A., Cook, S. M., Watt, A. P., Scott-Stevens, P., Rosahl, T. W., McKernan, R. M., Pym, L. J., Guiblin, A., Moyes, C., Sohal, B. and Atack, J. R. (2007), Contribution of specific binding to the central benzodiazepine site to the brain concentrations of two novel benzodiazepine site ligands. Biopharm. Drug Dispos., 28: 275–282. doi: 10.1002/bdd.553

Author Information

  1. 1

    Department of Medicinal Chemistry, Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow CM20 2QR, UK

  2. 2

    Department of In Vivo Neuroscience, Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow CM20 2QR, UK

  3. 3

    Department of Molecular Biology and Biochemistry, Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow CM20 2QR, UK

  1. †

    Astex Therapeutics, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, UK

*Department of Medicinal Chemistry, Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow CM20 2QR, UK

Publication History

  1. Issue published online: 18 JUN 2007
  2. Article first published online: 14 JUN 2007
  3. Manuscript Accepted: 23 JAN 2007
  4. Manuscript Revised: 10 JAN 2007
  5. Manuscript Received: 30 JUN 2006

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