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In vivo saturation binding of GABA-A receptor ligands to estimate receptor occupancy using liquid chromatography/tandem mass spectrometry

  1. Seth C. Hopkins1,*,
  2. J. Brian Nofsinger2,
  3. Michael S. Allen2,
  4. Patrick Koch1,
  5. Mark A. Varney1,†

Article first published online: 16 JAN 2009

DOI: 10.1002/bdd.641

Issue

Biopharmaceutics & Drug Disposition

Biopharmaceutics & Drug Disposition

Volume 30, Issue 1, pages 9–20, January 2009

Additional Information

How to Cite

Hopkins, S. C., Brian Nofsinger, J., Allen, M. S., Koch, P. and Varney, M. A. (2009), In vivo saturation binding of GABA-A receptor ligands to estimate receptor occupancy using liquid chromatography/tandem mass spectrometry. Biopharm. Drug Dispos., 30: 9–20. doi: 10.1002/bdd.641

Author Information

  1. 1

    Sepracor Inc., Marlborough, MA, USA

  2. 2

    Enthalpy Analytical, Durham, NC, USA

  1. †

    Cortex Pharmaceuticals, Irvine, CA, USA.

*Sepracor Inc., 84 Waterford Drive, Marlborough, MA 01752, USA

Publication History

  1. Issue published online: 27 JAN 2009
  2. Article first published online: 16 JAN 2009
  3. Manuscript Accepted: 18 DEC 2008
  4. Manuscript Revised: 5 DEC 2008
  5. Manuscript Received: 19 DEC 2007

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    Current literature in mass spectrometry, Journal of Mass Spectrometry, 2009, 44, 8
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