This article is a US Government work and, as such, is in the public domain in the United States of America.Presented as a poster at the 2006 Congress of Epidemiology, a joint meeting of the American College of Epidemiology, Epidemiology Section of the American Public Health Association, and the Society for Epidemiologic Research, June 21–24, 2006, in Seattle, Washington.Presented as a poster at the 9th annual meeting of the National Birth Defects Prevention Network, January 30–February 1, 2006, in Arlington, Virginia.The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention/the Agency for Toxic Substances and Disease Registry.
Reduction in orofacial clefts following folic acid fortification of the U.S. grain supply†
Article first published online: 19 DEC 2006
Copyright © 2006 Wiley-Liss, Inc.
Birth Defects Research Part A: Clinical and Molecular Teratology
Volume 79, Issue 1, pages 16–23, January 2007
How to Cite
Yazdy, M. M., Honein, M. A. and Xing, J. (2007), Reduction in orofacial clefts following folic acid fortification of the U.S. grain supply. Birth Defects Research Part A: Clinical and Molecular Teratology, 79: 16–23. doi: 10.1002/bdra.20319
- Issue published online: 4 JAN 2007
- Article first published online: 19 DEC 2006
- Manuscript Accepted: 12 SEP 2006
- Manuscript Revised: 6 SEP 2006
- Manuscript Received: 30 JUN 2006
- 2005. Maternal influenza during pregnancy and risk of congenital abnormalities in offspring. Birth Defects Res A Clin Mol Teratol 73: 989–996. , , , et al.
- 2006. Acute respiratory infections during pregnancy and congenital abnormalities: a population-based case-control study. Congen Anom 46: 86–96. , , , et al.
- 2001. Validity of birth certificate data for the outcome of the previous pregnancy, Georgia, 1980–1995.[see comment]. Am J Epidemiol 154: 883–888. .
- 2001. Are women with recent live births aware of the benefits of folic acid? MMWR Recomm Rep 50: 3–14. , .
- 2005. Perinatal epidemiologic research with vital statistics data: validity is the essential quality. Am J Obstet Gynecol 193: 5–6. .
- 2005. Folic acid supplementation and the occurrence of congenital heart defects, orofacial clefts, multiple births, and miscarriage. Am J Clin Nutr 81: 1213S–1217S. , .
- 1995. Effects of carbon monoxide and hypoxia on cleft lip in A/J mice. Cleft Palate Craniofac J 32: 14–19. , , .
- 2000. Surveillance for influenza—United States, 1994–95, 1995–96, and 1996–97 seasons. MMWR Surveill Summ 49: 13–28. , , , et al.
- 2002. Surveillance for influenza—United States, 1997–98, 1998–99, and 1999–00 seasons. MMWR Surveill Summ 51: 1–10. , , , et al.
- 1986. Morphogenesis of hypoxia-induced cleft lip in CL/Fr mice. J Craniofac Genet Dev Biol-Supplement 2: 113–128. , , .
- 2005. Changes in the birth prevalence of selected birth defects after grain fortification with folic acid in the United States: Findings from a multi-state population-based study. Birth Defects Res A Clin Mol Teratol 73: 679–689. , , , et al.
- Centers for Disease Control and Prevention. 1992. Recommendations for the Use of Folic Acid to Reduce the Number of Cases of Spina Bifida and Other Neural Tube Defects. MMWR 41(RR-14): 001.
- Centers for Disease Control and Prevention. 2006. Improved national prevalence estimates for 18 selected major birth defects-United States, 1999–2001. MMWR 54: 1301–1305.
- 1987. Average run length of exponentially weighted moving average charts. J Qual Technol 19: 161–164. .
- 1993. Prevention of congenital abnormalities by periconceptional multivitamin supplementation. BMJ 306: 1645–1648. .
- 1999. Dose-dependent effect of folic acid on the prevention of orofacial clefts. Pediatrics 104: e66. , , .
- 1996. Population-based case control study of folic acid supplementation during pregnancy. Teratology 53: 345–351. , , .
- 2002. Reliability of birth certificate data: a multi-hospital comparison to medical records information. Maternal Child Health J 6: 169–179. , , , et al.
- 1998. How well do birth certificates describe the pregnancies they report? The Washington State experience with low-risk pregnancies. Maternal Child Health J 2: 145–154. , , , et al.
- Food and Drug Administration. 1996. Food Standards. Fed Reg 61: 8781–8797.
- 1998. Impact of prenatal diagnosis and elective termination on the prevalence of selected birth defects in Hawaii. Am J Epidemiol 148: 1206–1211. , , .
- 1988. The 1989 revisions of the US Standard Certificates of Live Birth and Death and the US Standard Report of Fetal Death. Am J Public Health 78: 168–172. , , , et al.
- 2005. Pregnancy Planning Status and Health Behaviors Among Nonpregnant Women in a California Managed Health Care Organization. Perspect Sexual Reprod Health 37: 179–183. , , , et al.
- 1996. Case-control study of periconceptional folic acid supplementation and oral clefts. Am J Epidemiol 143: 1229–1234. , , , et al.
- 1988. Maternal drug histories and congenital malformations: limb reduction defects and oral clefts. J Epidemiol Community Health 42: 1–7. , , , et al.
- 2001. Impact of folic acid fortification of the US food supply on the occurrence of neural tube defects. JAMA 285: 2981–2986. , , , et al.
- Institute of Medicine. 1988. Prenatal Care: Reaching Mothers, Reaching Infants. BrownSS, editor. Washington DC: National Academy Press.
- 2001. Maternal multivitamin use and orofacial clefts in offspring. Teratology 63: 79–86. , , , et al.
- 1999. The Effect of Folic Acid Fortification on Plasma Folate and Total Homocysteine Concentrations. N Engl J Med 340: 1449–1454. , , , et al.
- 2000. Permutation tests for joinpoint regression with applications to cancer rates.[erratum appears in Stat Med 20:655]. Stat Med 19: 335–351. , , , et al.
- 1999. Trends in serum folate after food fortification. Lancet 354: 915–916. , , , et al.
- 2000. Lips and oral cavities. In: StevensonR,HallJ,GoodmanR, editors. Human malformations and related anomalies. New York: Oxford University Press. .
- 2004. Tobacco smoking and oral clefts: a meta-analysis. Bull WHO 82: 213–218. , , .
- 2001. Oral clefts and vitamin supplementation. Cleft Palate Craniofac J 38: 76–83. , , , et al.
- 1990. Exponentially weighted moving average control schemes: properties and enhancements. Technometrics 32: 1–12. , .
- 2003. Tobacco smoke exposure and decreased serum and red blood cell folate levels: data from the Third National Health and Nutrition Examination Survey. Nicotine Tobacco Res 5: 357–362. , , , et al.
- 1997. Low concentrations of folate in serum and erythrocytes of smokers: methionine loading decreases folate concentrations in serum of smokers and nonsmokers. Clin Chem 43: 2192–2194. , , , et al.
- 1998. Births of Hispanic origin, 1989–95. Mon Vital Stat Rep 46: 1–28. , , , et al.
- 2005. Maternal diseases and isolated orofacial clefts in Hungary. Birth Defects Res 73: 617–623. , , .
- 1981. Hyperoxia and hypoxia in pregnancy: simple experimental manipulation alters the incidence of cleft lip and palate in CL/Fr mice. Proc Natl Acad Sci USA 78: 5722–5723. , .
- National Cancer Institute. 2003. Joinpoint Regression Program. Version 2.7. http://srab.cancer.gov/joinpoint.
- 2001. The miseries of passive smoking. Hum Exp Toxicol 20: 61–83. .
- 2000. Psychosocial factors and the timing of prenatal care among women in New Jersey's HealthStart program. Family Planning Perspect 32: 56–64. , .
- 1993. Validation of 1989 Tennessee birth certificates using maternal and newborn hospital records. Am J Epidemiol 137: 758–768. , , , et al.
- 1994. Local and systemic effects of cigarette smoking on folate and vitamin B-12. Am J Clin Nutr 60: 559–566. , , , et al.
- 2003. Association between folic acid food fortification and congenital orofacial clefts. J Pediatr 143: 805–807. , , , et al.
- 1973. Letter: Smoking hazards to the fetus. Br Med J 4: 51. , , .
- 1998. Pregnancy intentions, pregnancy attitudes, and the use of prenatal care in Missouri. Maternal Child Health J 2: 155–165. , .
- 1974. Cleft lip and palate in Finland: parental histories, course of pregnancy and selected environmental factors. Int J Epidemiol 3: 263–270. .
- 1995. Risks of orofacial clefts in children born to women using multivitamins containing folic acid periconceptionally. Lancet 346: 393–396. , , , et al.
- 2004. Birth defects in Arkansas: Is folic acid fortification making a difference? Birth Defects Res 70: 559–564. , , , et al.
- 2005. Intent to become pregnant as a predictor of exposures during pregnancy: is there a relation? J Reprod Med 50: 389–396. , , , et al.
- 1987. Orofacial clefts in Czechoslovakia. Incidence, genetics and prevention of cleft lip and palate over a 19-year period. Scand J Plast Reconstr Surg Hand Surg 21: 19–25. .
- 1995. Reduced recurrence of orofacial clefts after periconceptional supplementation with high-dose folic acid and multivitamins. Teratology 51: 71–78. , .
- 2004. Periconceptional folate intake by supplement and food reduces the risk of nonsyndromic cleft lip with or without cleft palate. Prev Med 39: 689–694. , , , et al.
- 2001. Smoking, genetic polymorphisms in biotransformation enzymes, and nonsyndromic oral clefting: a gene-environment interaction. Epidemiology 12: 502–507. , , , et al.
- 1996. The surveillance of birth defects: the usefulness of the revised US standard birth certificate. Am J Public Health 86: 731–734. , , , et al.
- 1999. Multivitamin supplementation and risk of birth defects. Am J Epidemiol 150: 675–682. , , , et al.
- 2002. Prevalence of spina bifida and anencephaly during the transition to mandatory folic acid fortification in the United States. Teratology 66: 33–39. , , , et al.