Aplasia cutis congenita with skull defect in a monozygotic twin after exposure to methimazole in utero
Article first published online: 5 SEP 2007
Copyright © 2007 Wiley-Liss, Inc.
Birth Defects Research Part A: Clinical and Molecular Teratology
Volume 79, Issue 10, pages 680–684, October 2007
How to Cite
Iwayama, H., Hosono, H., Yamamoto, H., Oshiro, M. and Ueda, N. (2007), Aplasia cutis congenita with skull defect in a monozygotic twin after exposure to methimazole in utero. Birth Defects Research Part A: Clinical and Molecular Teratology, 79: 680–684. doi: 10.1002/bdra.20395
- Issue published online: 8 OCT 2007
- Article first published online: 5 SEP 2007
- Manuscript Accepted: 16 JUL 2007
- Manuscript Revised: 31 MAY 2007
- Manuscript Received: 31 MAR 2007
- aplasia cutis congenita;
- skull defect;
- monozygotic twin
Aplasia cutis congenita (ACC) is a condition in which localized or widespread areas of skin are absent at birth. Defective lesions show complete absence of all layers of skin, occasionally extending to skull or dura. ACC is etiologically heterogeneous; many different etiologies including teratogens have been documented.
We describe the first reported case of a monozygotic twin with ACC after exposure to methimazole in utero. The female patient was born at 36 weeks gestation as the first child of monozygotic twins. The mother received methimazole between the 11th and 17th weeks of pregnancy because of transient hyperthyroidism. The second child did not have ACC. The patient had defects of the scalp, skull, and dura (7 × 5 cm) on the sagittal line of the parieto-occipital region. No other malformations were noted. The scalp defect has been treated daily with sterile physiological saline and petrolatum dressing in addition to intravenous antibiotics. Trafermin, a recombinant human fibroblast growth factor, was sprayed from day 6 to promote epithelialization of the scalp defect. On day 21, she had high fever due to infection of the defect lesion, which was controlled by povidone iodine dressing and intravenous antibiotics. The defect of the scalp was well healed after 6 weeks, but the skull defect remained unclosed.
We describe a rare case of a monozygotic twin with ACC and skull defect after methimazole exposure in utero. The findings of our case suggest that methimazole is a potential teratogen of ACC. Birth Defects Research (Part A) 2007. © 2007 Wiley-Liss, Inc.