Presented at the 47th Annual Meeting of the Teratology Society, June 25–28, 2007, Pittsburgh, PA.
Nutrient intakes in women and congenital diaphragmatic hernia in their offspring†
Article first published online: 7 JAN 2008
Copyright © 2008 Wiley-Liss, Inc.
Birth Defects Research Part A: Clinical and Molecular Teratology
Volume 82, Issue 3, pages 131–138, March 2008
How to Cite
Yang, W., Shaw, G. M., Carmichael, S. L., Rasmussen, S. A., Waller, D. K., Pober, B. R. and Anderka, M. (2008), Nutrient intakes in women and congenital diaphragmatic hernia in their offspring. Birth Defects Research Part A: Clinical and Molecular Teratology, 82: 131–138. doi: 10.1002/bdra.20436
The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the National Center on Birth Defects and Developmental Disabilities or of the Centers for Disease Control and Prevention.
- Issue published online: 12 MAR 2008
- Article first published online: 7 JAN 2008
- Manuscript Revised: 8 NOV 2007
- Manuscript Accepted: 8 NOV 2007
- Manuscript Received: 18 SEP 2007
- Centers for Disease Control and Prevention, Centers of Excellence Award. Grant Number: U50/CCU913241
- NIH. Grant Number: RO1 HD55150 (B. R. P.)
- NIH. Grant Number: DK56350 (funds for part of the nutrient database work, granted to the University of North Carolina Department of Nutrition Clinical Research Center, Nutrition Epidemiology Core)
- congenital diaphragmatic hernia;
- vitamin supplements
BACKGROUND: Congenital diaphragmatic hernia (CDH) is a severe birth defect where there is an opening in the diaphragm through which a portion of the abdominal contents protrudes into the thoracic cavity. The etiologies of CDH remain unknown, although experimental animal data suggest dietary factors might play a role. This study examined whether maternal nutrient intakes were associated with delivering infants with CDH. METHODS: We analyzed infants with isolated CDH who were born from 1997 to 2003 and recruited into the National Birth Defects Prevention Study (NBDPS), a multisite, population-based case-control study. Exposure data were obtained from telephone interviews, which were completed within 24 months after delivery, and were available for 377 case mothers and 5,008 control mothers. A food frequency questionnaire was used to derive nutrient intakes during the year before pregnancy. RESULTS: A crude OR of 0.6 (95% CI: 0.3–1.0) was observed for higher intake of choline. Elevated ORs (1.4 to 1.7) were found for lower intakes of choline, cysteine, methionine, and protein. Among women who took vitamin supplements, higher intakes of B vitamins (i.e., folate, vitamin B1, B2, B6, and B12), minerals (i.e., calcium, iron, magnesium, and zinc), and vitamin E were inversely associated with CDH (ORs from 0.7–0.3). Moreover, among women who did not take vitamin supplements, lower intakes of calcium, retinol, selenium, vitamin B12, and vitamin E had positive associations with CDH (ORs from 1.4 to 2.1). CONCLUSIONS: Our observations contribute to a limited body of evidence suggesting a woman's periconceptional diet might be associated with CDH in her offspring. Birth Defects Research (Part A), 2008. © 2007 Wiley-Liss, Inc.