Zoonotic Ljungan virus associated with central nervous system malformations in terminated pregnancy
Article first published online: 29 JAN 2009
Copyright © 2009 Wiley-Liss, Inc.
Birth Defects Research Part A: Clinical and Molecular Teratology
Volume 85, Issue 6, pages 542–545, June 2009
How to Cite
Niklasson, B., Samsioe, A., Papadogiannakis, N., Gustafsson, S. and Klitz, W. (2009), Zoonotic Ljungan virus associated with central nervous system malformations in terminated pregnancy. Birth Defects Research Part A: Clinical and Molecular Teratology, 85: 542–545. doi: 10.1002/bdra.20568
- Issue published online: 9 JUN 2009
- Article first published online: 29 JAN 2009
- Manuscript Accepted: 14 OCT 2008
- Manuscript Revised: 12 OCT 2008
- Manuscript Received: 30 AUG 2008
- National Institutes of Health. Grant Number: NIDDK064365
The Ljungan virus (LV) has been shown to cause central nervous system malformations in laboratory mouse models. The LV has also been associated with intrauterine fetal death in humans. We investigated the presence of LV in a series of human hydrocephaly and anencephaly cases from elective abortions.
A series of elective abortions owing to hydrocephaly, anencephaly, and similarly aged trisomy 21 elective abortions as controls were examined for LV by immunohistochemistry and real time RT-PCR. A second experiment involved newborn mice exposed to LV.
LV was diagnosed in 9 of 10 cases with hydrocephalus and in 1 of 18 trisomy 21 controls by immunohistochemistry. Five of nine cases with anencephaly had a positive PCR result, whereas none of the 12 trisomy 21 available for PCR testing had a positive result. The 47 newborn mice exposed to LV all developed encephalitis, with eight having hydrocephalus. None of the 52 control animals had encephalitis or hydrocephalus.
The association between LV and both hydrocephaly and anencephaly suggests that LV may be playing an important role in central nervous system malformations in humans. Birth Defects Research (Part A), 2009. © 2009 Wiley-Liss, Inc.