Primary microcephaly in two children born to mothers with complicated appendicitis or late appendectomy during pregnancy
Article first published online: 23 FEB 2009
Copyright © 2009 Wiley-Liss, Inc.
Birth Defects Research Part A: Clinical and Molecular Teratology
Volume 85, Issue 7, pages 655–656, July 2009
How to Cite
Ács, N., Bánhidy, F. and Czeizel, A. E. (2009), Primary microcephaly in two children born to mothers with complicated appendicitis or late appendectomy during pregnancy. Birth Defects Research Part A: Clinical and Molecular Teratology, 85: 655–656. doi: 10.1002/bdra.20569
- Issue published online: 8 JUL 2009
- Article first published online: 23 FEB 2009
- Manuscript Accepted: 10 DEC 2008
- Manuscript Revised: 13 NOV 2008
- Manuscript Received: 1 SEP 2008
BACKGROUND: The possible association between maternal appendicitis/appendectomy during pregnancy and congenital abnormalities in the offspring was studied. CASES: Two cases with primary microcephaly were born to mothers who had complicated appendicitis owing to the delay of appendectomy resulting in abscess/peritonitis associated with septicemia and fever in the second trimester of pregnancy. CONCLUSIONS: Delay in surgical intervention of appendicitis in pregnancy can result in maternal morbidity that may be associated with primary microcephaly in the offspring. Birth Defects Research (Part A), 2009. © 2009 Wiley-Liss, Inc.