The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention. No conflict of interest is declared.
Maternal caffeine consumption and risk of neural tube defects†
Article first published online: 26 AUG 2009
Copyright © 2009 Wiley-Liss, Inc.
Birth Defects Research Part A: Clinical and Molecular Teratology
Special Issue: 2009 Congenital Malformation Surveillance Report: A Report from the National Birth Defects Prevention Network Part I
Volume 85, Issue 11, pages 879–889, November 2009
How to Cite
Schmidt, R. J., Romitti, P. A., Burns, T. L., Browne, M. L., Druschel, C. M. and Olney, R. S. (2009), Maternal caffeine consumption and risk of neural tube defects. Birth Defects Research Part A: Clinical and Molecular Teratology, 85: 879–889. doi: 10.1002/bdra.20624
- Issue published online: 10 NOV 2009
- Article first published online: 26 AUG 2009
- Manuscript Accepted: 9 JUL 2009
- Manuscript Revised: 26 JUN 2009
- Manuscript Received: 15 APR 2009
- Centers for Disease Control and Prevention. Grant Number: U50/CCU 713238
- neural tube defect;
- spinal dysraphism;
Animal studies demonstrate teratogenic effects of caffeine, whereas human studies are inconclusive.
Associations between maternal caffeine consumption and neural tube defects (NTDs) by type of NTD (anencephaly, spina bifida, or encephalocele) were examined using data from the National Birth Defects Prevention Study (NBDPS). Total average daily caffeine from coffee, tea, soda, and chocolate consumption during the year before pregnancy was estimated for 768 mothers of infants with NTDs and 4143 mothers of infants without birth defects who gave birth during 1997 through 2002. Periconceptional use of caffeine-containing medications was evaluated separately. Adjusted odds ratios (OR) and 95% confidence intervals (CI) associated with consumption of total caffeine and each caffeine source were estimated from logistic regression models.
Positive associations were observed between spina bifida and total caffeine consumption (OR 1.4; 95% CI: 1.1–1.9) and each caffeine source except caffeinated tea, which showed a negative association with spina bifida (OR 0.7; 95% CI: 0.6–0.9). Associations with modestly increased risk of NTDs and encephalocele were also observed. The association between caffeine consumption and anencephaly differed by maternal race/ethnicity. No dose effects were found.
Additional studies should confirm whether women who consume caffeine are at increased risk for pregnancies complicated by NTDs. Birth Defects Research (Part A) 2009. © 2009 Wiley-Liss, Inc.