Supported by grants from the Canadian Institutes of Health Research.
Epigenetic programming: From gametes to blastocyst†
Article first published online: 21 MAR 2011
Copyright © 2011 Wiley-Liss, Inc.
Birth Defects Research Part A: Clinical and Molecular Teratology
Special Issue: Epigenetic Processes in Development
Volume 91, Issue 8, pages 652–665, August 2011
How to Cite
Hales, B. F., Grenier, L., Lalancette, C. and Robaire, B. (2011), Epigenetic programming: From gametes to blastocyst. Birth Defects Research Part A: Clinical and Molecular Teratology, 91: 652–665. doi: 10.1002/bdra.20781
- Issue published online: 5 AUG 2011
- Article first published online: 21 MAR 2011
- Manuscript Accepted: 7 DEC 2010
- Manuscript Revised: 1 DEC 2010
- Manuscript Received: 14 OCT 2010
- Canadian Institutes of Health Research
- early embryos;
- DNA methylation;
- noncoding RNA
Embryo development requires a series of cell fate decisions; cell lineages are established early during development and must be “remembered” through multiple cell divisions. It is increasingly evident that epigenetic marks, DNA methylation, histone modifications, and noncoding RNAs, have a critical role in this cell memory during development. During gametogenesis, epigenetic programming results in the production of spermatozoa and oocytes with distinctive chromatin. The goal of this article is to review what is known about the epigenetic marks in mature gametes and how these marks change during early embryo development. An understanding of the role of epigenetic programming during normal development will lay the basis for the elucidation of its role when development goes awry and the consequence is a birth defect. Birth Defects Research (Part A) 2011. © 2011 Wiley-Liss, Inc.