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In utero exposure to bisphenol-A and anogenital distance of male offspring

Authors

  • Maohua Miao,

    1. Division of Research, Kaiser Foundation Research Institute, Kaiser Permanente, Oakland, California
    2. Department of Epidemiology and Social Science on Reproductive Health, Shanghai Institute of Planned Parenthood Research, World Health Organization Collaborating Center for Research in Human Reproduction, National Population and Family Planning Key Laboratory of Contraceptive Drugs and Devices, Shanghai, China
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  • Wei Yuan,

    Corresponding author
    1. Department of Epidemiology and Social Science on Reproductive Health, Shanghai Institute of Planned Parenthood Research, World Health Organization Collaborating Center for Research in Human Reproduction, National Population and Family Planning Key Laboratory of Contraceptive Drugs and Devices, Shanghai, China
    • Department of Epidemiology and Social Science on Reproductive Health, Shanghai Institute of Planned Parenthood Research, Shanghai, China, 200032
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  • Yonghua He,

    1. Department of Occupational Health and Toxicology, School of Public Health and World Health Organization Collaborating Center for Occupational Health, Fudan University, Shanghai, China
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  • Zhijun Zhou,

    1. Department of Occupational Health and Toxicology, School of Public Health and World Health Organization Collaborating Center for Occupational Health, Fudan University, Shanghai, China
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  • Jintao Wang,

    1. Department of Epidemiology, Shanxi Medical University, Taiyuan, China
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  • Ersheng Gao,

    1. Department of Epidemiology and Social Science on Reproductive Health, Shanghai Institute of Planned Parenthood Research, World Health Organization Collaborating Center for Research in Human Reproduction, National Population and Family Planning Key Laboratory of Contraceptive Drugs and Devices, Shanghai, China
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  • Guohong Li,

    1. Institute for the Prevention and Treatment of Occupational Diseases, Baling Petrochemical Company, Yueyang, China
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  • De-Kun Li

    Corresponding author
    1. Division of Research, Kaiser Foundation Research Institute, Kaiser Permanente, Oakland, California
    • Division of Research, Kaiser Permanente Northern California, 2000 Broadway, Oakland, CA 94612
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  • Presented at the 43rd annual meeting of the Society for Epidemiological Research, June 23–25, 2010, Seattle, Washington.

  • Supported by a grant from the U.S. National Institute of Occupational Safety and Health (R01 OH007580) and by the National basic research program of China (973 program) 2010CB529505

Abstract

BACKGROUND

Bisphenol-A (BPA) is an endocrine disruptor with widespread human exposure. The effect of in utero BPA exposure on human offspring remains largely unknown.

METHODS

Anogenital distance (AGD) of sons of workers who did or did not have occupational BPA exposure during pregnancy were compared in an occupational cohort study. Parental BPA exposure level during the index pregnancy was estimated through a job-exposure matrix based on personal air sampling measurement. Maternal exposure was considered direct in utero exposure to the fetus, whereas paternal exposure was considered indirect in utero exposure.

RESULTS

A total of 153 boys were included in the final analysis, among them 56 with parental occupational exposure during pregnancy and 97 without. After controlling for the boys' ages and weights using linear regression, parental occupational exposure to BPA during pregnancy was associated with shortened AGD in male offspring. The association was stronger for maternal exposure (p < 0.01). There was also a dose-response relationship with increased BPA exposure levels in pregnancy associated with greater magnitude of shortened AGD in male offspring, with a statistically significant trend for the association (p = 0.008).

CONCLUSION

Our findings provide the first epidemiologic evidence that in utero BPA exposure may adversely affect male genital development. Birth Defects Research (Part A) 91:867–872, 2011. © 2011 Wiley-Liss, Inc.

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