Grants: This work was supported in part through a cooperative agreement (U01DD000494) between the Centers for Disease Control and Prevention and the Texas Department of State Health Services (DSHS). It was also partly supported by Title V Maternal and Child Health Block Grants Funds from the Office of Title V and Family Health.
Descriptive epidemiology of selected heritable birth defects in Texas†
Article first published online: 19 NOV 2011
Copyright © 2011 Wiley Periodicals, Inc.
Birth Defects Research Part A: Clinical and Molecular Teratology
Special Issue: 2011 Congenital Malformations Surveillance Report
Volume 91, Issue 12, pages 990–994, December 2011
How to Cite
Moffitt, K. B., Abiri, O. O., Scheuerle, A. E. and Langlois, P. H. (2011), Descriptive epidemiology of selected heritable birth defects in Texas. Birth Defects Research Part A: Clinical and Molecular Teratology, 91: 990–994. doi: 10.1002/bdra.22859
- Issue published online: 9 DEC 2011
- Article first published online: 19 NOV 2011
- Manuscript Accepted: 15 AUG 2011
- Manuscript Revised: 12 JUL 2011
- Manuscript Received: 2 MAY 2011
- Centers for Disease Control and Prevention and the Texas Department of State Health Services (DSHS). Grant Number: U01DD000494
- Title V Maternal and Child Health Block Grants Funds from the Office of Title V and Family Health
- aqueductal stenosis;
- infantile polycystic kidney disease;
- osteogenesis imperfecta
BACKGROUND Few population-based studies exist on descriptive epidemiologic characteristics of rare heritable birth defects. The number of birth defect cases in the Texas Birth Defects Registry (one of the largest active birth defects surveillance systems in the world) enabled us to examine six different heritable disorders (aqueductal stenosis, infantile polycystic kidney disease, achondroplasia, thanatophoric dwarfism, chondrodysplasia/dwarfism not otherwise specified (NOS), and osteogenesis imperfecta) for a variety of descriptive demographic variables. METHODS The Texas Birth Defects Registry was used to identify infants or fetuses with heritable birth defects. Crude prevalence rates were calculated and Poisson regression was used to test the association of each demographic variable (e.g., maternal age) with each of the selected genetic birth defects. RESULTS White non-Hispanics exhibited higher rates of achondroplasia and osteogenesis imperfecta than other race/ethnic groups. Lower maternal education level and to a lesser extent, paternal education level, was associated with higher rates of several disorders. The birth prevalence rate for achondroplasia decreased from 1999 through 2006. CONCLUSION The use of a large birth defects registry provides a sufficient count of cases to perform some basic epidemiologic analysis on selected rare heritable birth defects. Birth Defects Research (Part A) 2011. © 2011 Wiley Periodicals, Inc.