In partial fulillment of the requirements for the PhD degree, University of Haifa, Israel
Article first published online: 26 APR 2012
Copyright © 2012 Wiley Periodicals, Inc.
Birth Defects Research Part A: Clinical and Molecular Teratology
Volume 94, Issue 6, pages 438–448, June 2012
How to Cite
Agay-Shay, K., Friger, M., Linn, S., Peled, A., Amitai, Y. and Peretz, C. (2012), Periodicity and time trends in the prevalence of total births and conceptions with congenital malformations among Jews and Muslims in Israel, 1999-2006: A time series study of 823,966 births. Birth Defects Research Part A: Clinical and Molecular Teratology, 94: 438–448. doi: 10.1002/bdra.23010
Supported by the Israeli Ministry of Environmental Protection (research grant number-7-2-7) and by the Environment and Health fund (PhD Fellowship program).
K.A.S. participated in the conception, design, and planning of the study, performed data analysis, execution of research program, manuscript writing, and review of the literature. M.F. took part in the conception and interpretation of the statistical analysis and writing of the manuscript. S.L. took part in the study planning, manuscript review, and critical discussion. A.P. took part in the interpretation of the analysis and writing of the manuscript. Y.A. supplied data from participating registries, advice on data collection, classification of cases, and critical discussion. C.P. participated in the conception and design of the study and supervised the data analysis and revision of the manuscript. All authors saw and approved the final version of the manuscript.
The study was approved by the Ethics Committee of the University of Haifa. Further approvals from the director of Public Health Services and from the legal advisor in the Ministry of Health were also obtained. The investigators were provided with the CM data set only after deletion of all personal identifiers (e.g., ID numbers, name of mother).
- Issue published online: 11 JUN 2012
- Article first published online: 26 APR 2012
- Manuscript Accepted: 5 MAY 2012
- Manuscript Revised: 28 FEB 2012
- Manuscript Received: 9 JAN 2012
- Supported by the Israeli Ministry of Environmental Protection. Grant Number: -7-2-7
- Environment and Health fund
- PhD Fellowship program
- congenital malformations;
- birth defects;
- geophysical rhythm
BACKGROUND Congenital malformations (CMs) are a leading cause of infant disability. Geophysical patterns such as 2-year, yearly, half-year, 3-month, and lunar cycles regulate much of the temporal biology of all life on Earth and may affect birth and birth outcomes in humans. Therefore, the aim of this study was to evaluate and compare trends and periodicity in total births and CM conceptions in two Israeli populations. METHODS Poisson nonlinear models (polynomial) were applied to study and compare trends and geophysical periodicity cycles of weekly births and weekly prevalence rate of CM (CMPR), in a time-series design of conception date within and between Jews and Muslims. The population included all live births and stillbirths (n = 823,966) and CM (three anatomic systems, eight CM groups [n = 2193]) in Israel during 2000 to 2006. Data were obtained from the Ministry of Health. RESULTS We describe the trend and periodicity cycles for total birth conceptions. Of eight groups of CM, periodicity cycles were statistically significant in four CM groups for either Jews or Muslims. Lunar month and biennial periodicity cycles not previously investigated in the literature were found to be statistically significant. Biennial cycle was significant in total births (Jews and Muslims) and syndactyly (Muslims), whereas lunar month cycle was significant in total births (Muslims) and atresia of small intestine (Jews). CONCLUSION We encourage others to use the method we describe as an important tool to investigate the effects of different geophysical cycles on human health and pregnancy outcomes, especially CM, and to compare between populations. Birth Defects Research (Part A) 2012. © 2012 Wiley Periodicals, Inc.