This research was supported by the Centers for Disease Control and Prevention (5U01DD000491); and partially supported by the National Institutes of Health (RO1NS050249 to G.M.S.). Funds for part of the nutrient database work were provided by NIH DK56350 granted to the University of North Carolina Department of Nutrition Clinical Research Center, Nutrition Epidemiology Core.
Article first published online: 29 AUG 2012
Copyright © 2012 Wiley Periodicals, Inc.
Birth Defects Research Part A: Clinical and Molecular Teratology
Volume 94, Issue 11, pages 864–874, November 2012
How to Cite
Chandler, A. L., Hobbs, C. A., Mosley, B. S., Berry, R. J., Canfield, M. A., Qi, Y. P., Siega-Riz, A. M., Shaw, G. M. and National Birth Defects Prevention Study (2012), Neural tube defects and maternal intake of micronutrients related to one-carbon metabolism or antioxidant activity. Birth Defects Research Part A: Clinical and Molecular Teratology, 94: 864–874. doi: 10.1002/bdra.23068
The manuscript's contents are solely the responsibility of the authors and do not necessarily represent the official views of the Centers for Disease Control and Prevention or the California Department of Public Health. All authors have stated that they have no conflict of interest regarding this manuscript.
- Issue published online: 16 NOV 2012
- Article first published online: 29 AUG 2012
- Manuscript Accepted: 12 JUL 2012
- Manuscript Revised: 26 JUN 2012
- Manuscript Received: 12 APR 2012
- Centers for Disease Control and Prevention. Grant Number: 5U01DD000491
- National Institutes of Health. Grant Number: RO1NS050249
- NIH. Grant Number: DK56350
- University of North Carolina Department of Nutrition Clinical Research Center, Nutrition Epidemiology Core
- dietary periconceptional micronutrients;
- maternal nutrition;
- National Birth Defects Prevention Study;
- neural tube defects;
- one-carbon metabolism
Maternal nutritional status has been evaluated to clarify its role in development of neural tube defects (NTDs). Maternal folate intake during pregnancy has been closely evaluated for its association with NTDs. The study objective was to examine associations between NTDs and other dietary periconceptional micronutrient intake, particularly nutrients involved in one-carbon metabolism or antioxidant activity.
Using data from the National Birth Defects Prevention Study, 1997–2005, logistic regression models were used to estimate the relative risk of NTDs based on maternal micronutrient intake.
Results were stratified according to folic acid supplement use, race/ethnicity, and maternal body mass index. Analyses included 954 cases (300 with anencephaly, 654 with spina bifida) and 6268 controls. Higher intakes of folate, thiamin, betaine, iron, and vitamin A were associated with decreased risk of anencephaly among some ethnic and clinical groups. In some groups, higher intakes of thiamin, riboflavin, vitamin B6, vitamin C, vitamin E, niacin, and retinol were associated with decreased risk of spina bifida.
In addition to folic acid, other micronutrients, including thiamin, betaine, riboflavin, vitamin B6, vitamin C, vitamin E, niacin, iron, retinol, and vitamin A, may decrease the risk of NTD occurrence. Birth Defects Research (Part A) 2012. © 2012 Wiley Periodicals, Inc.