Supported by the American Heart Association (to P.J.L., grant no. 10BGIA3060022); cooperative agreements under PA 96043, PA 02081, and FOA DD09-001 from the Centers for Disease Control and Prevention (CDC) to the Centers for Birth Defects Research and Prevention participating in the National Birth Defects Prevention Study; Grant number: U01DD000494. The CDC to the Texas Department of State Health Services. Contract 200-2000-08018 from the CDC and the National Institute for Occupational Safety and Health.
Article first published online: 3 SEP 2012
Copyright © 2012 Wiley Periodicals, Inc.
Birth Defects Research Part A: Clinical and Molecular Teratology
Volume 94, Issue 11, pages 875–881, November 2012
How to Cite
Lupo, P. J., Symanski, E., Langlois, P. H., Lawson, C. C., Malik, S., Gilboa, S. M., Lee, L. J., Agopian, A. J., Desrosiers, T. A., Waters, M. A., Romitti, P. A., Correa, A., Shaw, G. M., Mitchell,, L. E. and and the National Birth Defects Prevention Study (2012), Maternal occupational exposure to polycyclic aromatic hydrocarbons and congenital heart defects among offspring in the national birth defects prevention study . Birth Defects Research Part A: Clinical and Molecular Teratology, 94: 875–881. doi: 10.1002/bdra.23071
The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention or the California Department of Public Health.
- Issue published online: 16 NOV 2012
- Article first published online: 3 SEP 2012
- Manuscript Accepted: 16 JUL 2012
- Manuscript Revised: 13 JUL 2012
- Manuscript Received: 19 JUN 2012
- The American Heart Association. Grant Number: 10BGIA3060022
- cooperative agreements under. Grant Numbers: PA 96043, PA 02081, FOA DD09-001
- the Centers for Disease Control and Prevention (CDC)
- Birth Defects Research and Prevention participating in the National Birth Defects Prevention Study. Grant Number: U01DD000494
- The CDC to the Texas Department of State Health Services. Grant Number: 200-2000-08018
- the CDC and the National Institute for Occupational Safety and Health
- birth defects;
- congenital heart defects;
- maternal occupation;
- polycyclic aromatic hydrocarbons
BACKGROUND:There is evidence in experimental model systems that exposure to polycyclic aromatic hydrocarbons (PAHs) results in congenital heart defects (CHDs); however, to our knowledge, this relationship has not been examined in humans. Therefore, we conducted a case-control study assessing the association between estimated maternal occupational exposure to PAHs and CHDs in offspring. METHODS:Data on CHD cases and control infants were obtained from the National Birth Defects Prevention Study for the period of 1997 to 2002. Exposure to PAHs was assigned by industrial hygienist consensus, based on self-reported maternal occupational histories from 1 month before conception through the third month of pregnancy. Logistic regression was used to evaluate the association between maternal occupational PAH exposure and specific CHD phenotypic subtypes among offspring. RESULTS:The prevalence of occupational PAH exposure was 4.0% in CHD case mothers (76/1907) and 3.6% in control mothers (104/2853). After adjusting for maternal age, race or ethnicity, education, smoking, folic acid supplementation, and study center, exposure was not associated with conotruncal defects (adjusted odds ratio [AOR], 0.98; 95% confidence interval [CI], 0.58–1.67), septal defects (AOR, 1.28; 95% CI, 0.86–1.90), or with any isolated CHD subtype. CONCLUSIONS:Our findings do not support an association between potential maternal occupational exposure to PAHs and various CHDs in a large, population-based study. For CHD phenotypic subtypes in which modest nonsignificant associations were observed, future investigations could be improved by studying populations with a higher prevalence of PAH exposure and by incorporating information on maternal and fetal genotypes related to PAH metabolism. Birth Defects Research (Part A), 2012. © 2012 Wiley Periodicals, Inc.