Occurrence and fate of fetal lumbar rib induced by Scutellariae radix in rats

Authors

  • Eun A. Ko,

    1. National Research Laboratory for Mitochondrial Signaling, FIRST Mitochondria Research Group, Department of Physiology and Biophysics, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, Busan, South Korea
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    • Eun A. Ko and Won Sun Park contributed equally to this work.

  • Won Sun Park,

    1. Department of Physiology, Kangwon National University School of Medicine, Chuncheon, South Korea
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    • Eun A. Ko and Won Sun Park contributed equally to this work.

  • Inja Lim,

    1. Department of Physiology, College of Medicine, Chung-Ang University, Seoul, South Korea
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  • Jihyun Yun,

    1. Department of Physiology, College of Medicine, Chung-Ang University, Seoul, South Korea
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  • Jung-Ha Kim,

    1. Department of Family Medicine, Chung-Ang University Medical Center, Seoul, South Korea
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  • Young-Ku Kang,

    1. Division of Public Health & Oriental Medicine, Jeollanam-do Provincial Government, Muan, South Korea
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  • Nari Kim,

    1. National Research Laboratory for Mitochondrial Signaling, FIRST Mitochondria Research Group, Department of Physiology and Biophysics, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, Busan, South Korea
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  • Jin Han,

    1. National Research Laboratory for Mitochondrial Signaling, FIRST Mitochondria Research Group, Department of Physiology and Biophysics, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, Busan, South Korea
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  • Hyoweon Bang,

    Corresponding author
    1. Department of Physiology, College of Medicine, Chung-Ang University, Seoul, South Korea
    • Department of Physiology, College of Medicine, Chung-Ang University 221 Heukseok-dong, Dongjak-gu, Seoul 156-756, South Korea
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  • Jae-Hong Ko

    Corresponding author
    1. Department of Physiology, College of Medicine, Chung-Ang University, Seoul, South Korea
    • Department of Physiology, College of Medicine, Chung-Ang University 221 Heukseok-dong, Dongjak-gu, Seoul 156-756, South Korea
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Abstract

BACKGROUND: This study was conducted to evaluate the occurrence and fate of fetal lumbar rib induced by Scutellariae radix (SR) in rats. METHODS: Water extracts of SR were orally administered to pregnant rats from day 7 to day 17 of gestation at a dose of 186 mg/kg/day, equivalent to 25 g/kg of starting material, representing a 100-fold increase over typical human intake level. RESULTS: The incidence of fetal lumbar rib in the SR-treated group was increased on gestational day 20 and then decreased on postnatal day 50. The weight of fetuses in the SR-treated group tended to be less than that in the control group. Alkaline phosphatase in SR-treated dams was increased on gestational day 20, but was decreased on postnatal day 50. There were no significant differences between the vehicle control and SR-treated groups in maternal body weight, embryological, histopathological, hematological, and serum biochemical changes. CONCLUSIONS: The present data suggest that the appearance of lumbar rib induced by SR is a transient fetal variation rather than teratogenicity or maternal toxicity. Birth Defects Res (Part B) 89:201–206, 2010. © 2010 Wiley-Liss, Inc.

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