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Effects of chlorpyrifos exposure on kidney Notch2–Jagged1 pathway of early prenatal embryo

Authors

  • Wenqing Chen,

    1. Kidney Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, People's Republic of China
    2. Kidney Disease Immunology Laboratory, The Third Grade Laboratory, State Administration of Traditional Chinese Medicine, People's Republic of China
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    • Wenqing Chen and Hong Jiang contribute equal to this paper.

  • Hong Jiang,

    1. Kidney Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, People's Republic of China
    2. Kidney Disease Immunology Laboratory, The Third Grade Laboratory, State Administration of Traditional Chinese Medicine, People's Republic of China
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    • Wenqing Chen and Hong Jiang contribute equal to this paper.

  • Minmin Wang,

    1. Kidney Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, People's Republic of China
    2. Kidney Disease Immunology Laboratory, The Third Grade Laboratory, State Administration of Traditional Chinese Medicine, People's Republic of China
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  • Juan Jin,

    1. Kidney Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, People's Republic of China
    2. Kidney Disease Immunology Laboratory, The Third Grade Laboratory, State Administration of Traditional Chinese Medicine, People's Republic of China
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  • Shi Feng,

    1. Kidney Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, People's Republic of China
    2. Kidney Disease Immunology Laboratory, The Third Grade Laboratory, State Administration of Traditional Chinese Medicine, People's Republic of China
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  • Yan Bi,

    1. Kidney Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, People's Republic of China
    2. Kidney Disease Immunology Laboratory, The Third Grade Laboratory, State Administration of Traditional Chinese Medicine, People's Republic of China
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  • Huiping Wang,

    1. Kidney Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, People's Republic of China
    2. Kidney Disease Immunology Laboratory, The Third Grade Laboratory, State Administration of Traditional Chinese Medicine, People's Republic of China
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  • Youying Mao,

    1. Kidney Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, People's Republic of China
    2. Kidney Disease Immunology Laboratory, The Third Grade Laboratory, State Administration of Traditional Chinese Medicine, People's Republic of China
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  • Zhangfei Shou,

    1. Kidney Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, People's Republic of China
    2. Kidney Disease Immunology Laboratory, The Third Grade Laboratory, State Administration of Traditional Chinese Medicine, People's Republic of China
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  • Jianghua Chen

    Corresponding author
    1. Kidney Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, People's Republic of China
    2. Kidney Disease Immunology Laboratory, The Third Grade Laboratory, State Administration of Traditional Chinese Medicine, People's Republic of China
    • Kidney Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Qinchun Road 79♯ Hangzhou 310003, People's Republic of China
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Abstract

Aims: To evaluate the effects of this insecticide on the embryonic development of kidney and to assess the important role of Notch2–Jagged1 pathway in this duration. Methods and results: Chlorpyrifos (CPF) 5 mg/kg/d were administrated on gestation 7.5–11.5 day by subcutaneous injection. On gestation 16.5 day, the normal embryo kidney developed through S shape duration to the original kidney, which had the nephrons and could start to secret the urine. But for the CPF-treated mice, the embryo kidney developed much more slowly, they did not show the S shape and the nephrons. The Notch2–Jagged1 pathway should be expressed stronger in the normal embryo kidney on gestation 16.5 day, but for the CPF-treated mice we found the obvious weak pathway staining. Conclusions: CPF broke the Notch2–Jagged1 pathway during the embryo kidney development, and the Notch2–Jagged1 pathway plays an important role in the S shape to original kidney formation duration. Birth Defects Res (Part B) 92:97–101, 2011. © 2011 Wiley-Liss, Inc.

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