Centers for Disease Control
congenital malformations (birth defects)
central nervous system
binding protein involved in transcription regulation
Food and Drug Administration
Health Environmental Science Institute
Human Health Services
International Life Science Institute
intrauterine growth retardation
mean residence time
mechanism of action
no adverse effect level
Organization of Teratology Information Specialists
post conception day (s)
spontaneous abortion (miscarriage)
small for gestational age (less than the 10th percentile for gestational age)
World Health Organization.
Evaluation of the reproductive and developmental risks of caffeine†
Version of Record online: 2 MAR 2011
© 2011 Wiley-Liss, Inc.
Birth Defects Research Part B: Developmental and Reproductive Toxicology
Volume 92, Issue 2, pages 152–187, April 2011
How to Cite
Brent, R. L., Christian, M. S. and Diener, R. M. (2011), Evaluation of the reproductive and developmental risks of caffeine. Birth Defects Research Part B: Developmental and Reproductive Toxicology, 92: 152–187. doi: 10.1002/bdrb.20288
This Teratogen Update of the reproductive and developmental risks of caffeine is dedicated to Mildred S. Christian, better known to her friends and colleagues as Millie. This manuscript is the third publication that Millie and I will have coauthored. She spent the last year of her life working on this manuscript with her usual indefatigable perseverance. In a recent published essay the author quoted his father's philosophy of life who said, “The young may die, but the old have to.” Whatever her age, Millie was young. She was young in spirit, enthusiasm, creativity, and productivity. Millie was a brilliant toxicologist and had a broad intellectual grasp of science. Because of her expertise, she was frequently consulted by pharmaceutical and chemical companies to analyze preclinical studies that needed an objective experienced toxicologist. She received accolades and praise from the entire teratology and toxicology community. Dr. Christian completed her doctorate in the Teratology-Developmental Biology Training Program at the Jefferson Medical College of Thomas Jefferson University. She was a good graduate student and was already planning her career. After receiving her Ph.D. she pursued toxicology consulting as a career. She was the co-founder of Argus Research Laboratories (now a Division of Charles River Laboratories) and President and CEO of Argus International, Inc. She was an Adjunct Associate Professor in the Department of Anatomy and Developmental Biology at Jefferson Medical College, Thomas Jefferson University since 1992 and an Adjunct Professor in the Department of Pharmacology and Toxicology at the University of Arkansas for Medical Sciences since 1997. She was a certified Diplomate in General Toxicology of The Academy of Toxicological Sciences. In addition, she was the Founding Editor of the International Journal of the American College of Toxicology and was its Editor-in-Chief for 10 years. Dr. Christian edited and/or contributed to several major textbooks and was the author of more than 100 papers and abstracts. Because of the high respect and admiration of Dr. Christian by the teratology community, she was elected President of the Teratology Society. Her year as President was a memorable experience. She accomplished so much for the Society that year because of her excellent administrative ability. Mildred S. Christian passed away on March 26, 2009, in Mechanicsville, Pennsylvania shortening the life of a wonderful human being and a tireless scientist. We all are saddened that both her productivity and her life have been shortened by her death. Above all she was a beautiful human being.
- Issue online: 11 APR 2011
- Version of Record online: 2 MAR 2011
- Manuscript Accepted: 23 JAN 2011
- Manuscript Revised: 18 JAN 2011
- Manuscript Received: 29 SEP 2010
- International Life Sciences Institute
- Re-use of this article is permitted in accordance with the Terms and Conditions set out at [http://wileyonlinelibrary.com/author resources/onlineopen.html]
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