Grant sponsor: This research was supported by Ruth L. Kirschstein, National Research Service Award from the NIDA 1F32 DA021977 (D.P.), and NIH grants DA020531, AA018709 (K.Y.V.), AA015525 (B.H.), and DC011121 (R.L.H.).
Cannabinoid Receptor 1 Signaling in Embryo Neurodevelopment
Article first published online: 6 FEB 2012
© 2012 Wiley Periodicals, Inc.
Birth Defects Research Part B: Developmental and Reproductive Toxicology
Volume 95, Issue 2, pages 137–150, April 2012
How to Cite
Psychoyos, D., Vinod, K. Y., Cao, J., Xie, S., Hyson, R. L., Wlodarczyk, B., He, W., Cooper, T. B., Hungund, B. L. and Finnell, R. H. (2012), Cannabinoid Receptor 1 Signaling in Embryo Neurodevelopment. Birth Defects Research Part B: Developmental and Reproductive Toxicology, 95: 137–150. doi: 10.1002/bdrb.20348
- Issue published online: 23 APR 2012
- Article first published online: 6 FEB 2012
- Manuscript Accepted: 18 OCT 2011
- Manuscript Received: 18 AUG 2011
- NIDA. Grant Number: 1F32 DA021977
- NIH. Grant Numbers: DA020531, AA018709, AA015525, DC011121
In utero exposure to tetrahydrocannabinol, the psychoactive component of marijuana, is associated with an increased risk for neurodevelopmental defects in the offspring by interfering with the functioning of the endocannabinoid (eCB) system. At the present time, it is not clearly known whether the eCB system is present before neurogenesis. Using an array of biochemical techniques, we analyzed the levels of CB1 receptors, eCBs (AEA and 2-AG), and the enzymes (NAPE-PLD, DAGLα, DAGLβ, MAGL, and FAAH) involved in the metabolism of the eCBs in chick and mouse models during development. The findings demonstrate the presence of eCB system in early embryo before neurogenesis. The eCB system might play a critical role in early embryogenesis and there might be adverse developmental consequences of in utero exposure to marijuana and other drugs of abuse during this period.