Matrix loading: Assembly of extracellular matrix collagen fibrils during embryogenesis
Article first published online: 25 MAR 2004
Copyright © 2004 Wiley-Liss, Inc.
Birth Defects Research Part C: Embryo Today: Reviews
Volume 72, Issue 1, pages 1–11, March 2004
How to Cite
Kadler, K. (2004), Matrix loading: Assembly of extracellular matrix collagen fibrils during embryogenesis. Birth Defects Research Part C: Embryo Today: Reviews, 72: 1–11. doi: 10.1002/bdrc.20002
- Issue published online: 25 MAR 2004
- Article first published online: 25 MAR 2004
- Wellcome Trust
- collagen fibrils;
- extracellular matrix
Nothing in biology stimulates the imagination like the development of a single fertilized egg into a newborn child. Consequently, a major focus of biomedical research is aimed at understanding cell differentiation, proliferation, and specialization during child health and human development. However, the fact that the increase in size and shape of the growing embryo has as much to do with the extracellular matrix (ECM) as with the cells themselves, is largely overlooked. Cells in developing tissues are surrounded by a fiber-composite ECM that transmits mechanical stimuli, maintains the shape of developing tissues, and functions as a scaffold for cell migration and attachment. The major structural element of the ECM is the collagen fibril. The fibrils, which are indeterminate in length, are arranged in different tissues in exquisite supramolecular architectures, including parallel bundles, orthogonal lamellae, and concentric weaves. This article reviews our current understanding of the synthesis and assembly of collagen fibrils, and discusses challenging questions about how cells assemble an organized ECM during embryogenesis. Birth Defects Research (Part C) 72:1–11, 2004. © 2004 Wiley-Liss, Inc.