Muscle function and dysfunction in health and disease
Article first published online: 26 SEP 2005
Copyright © 2005 Wiley-Liss, Inc.
Birth Defects Research Part C: Embryo Today: Reviews
Volume 75, Issue 3, pages 180–192, September 2005
How to Cite
Huh, M. S., Smid, J. K. and Rudnicki, M. A. (2005), Muscle function and dysfunction in health and disease. Birth Defects Research Part C: Embryo Today: Reviews, 75: 180–192. doi: 10.1002/bdrc.20045
- Issue published online: 26 SEP 2005
- Article first published online: 26 SEP 2005
- Canadian Institutes of Health Research
- National Institutes of Health
- Muscular Dystrophy Association
- Canada Research Chair Program
Skeletal muscles of the trunk and limbs developmentally originate from the cells of the dermomyotomal compartment of the somite. A wealth of knowledge has been accumulated with regard to understanding the molecular regulation of embryonic skeletal myogenesis. Myogenic induction is controlled through a complex series of spatiotemporal dependent signaling cascades. Secreted signaling molecules from surrounding structures not only initiate the myogenic program, but also influence proliferation and differentiation decisions. The proper coordination of these molecular events is thus critical for the formation of physiologically functional skeletal muscles. Hereditary congenital skeletal muscle defects arise due to genetics lesions in myogenic specific components. Understanding the mechanistic routes of congenital skeletal muscle disease therefore requires a comprehensive knowledge of the developmental system. Ultimately, the application of this knowledge will improve the diagnostic and therapeutic methodologies for such diseases. The aim of this review is to overview our current understanding of skeletal muscle development and associated human congenital diseases. Birth Defects Research (Part C) 75:180–192, 2005. © 2005 Wiley-Liss, Inc.