Long-term Effects of Prenatal Stress and Glucocorticoid Exposure
Article first published online: 29 JAN 2013
Copyright © 2013 Wiley Periodicals, Inc.
Birth Defects Research Part C: Embryo Today: Reviews
Volume 96, Issue 4, pages 315–324, December 2012
How to Cite
Painter, R. C., Roseboom, T. J. and de Rooij, S. R. (2012), Long-term Effects of Prenatal Stress and Glucocorticoid Exposure. Birth Defects Research Part C: Embryo Today: Reviews, 96: 315–324. doi: 10.1002/bdrc.21021
- Issue published online: 29 JAN 2013
- Article first published online: 29 JAN 2013
- Manuscript Accepted: 7 NOV 2012
- Manuscript Received: 31 AUG 2012
There is a growing body of evidence suggesting that events during prenatal life can have long-lasting effects on development and adult health. Stress during pregnancy is common and has been linked to increased incidence of a range of affective and behavioral outcomes in the offspring in later life and also some somatic outcomes. Glucocorticoids, and their actions on the fetus, which are regulated by placental 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2), are hypothesized to mediate these effects. Animal studies have demonstrated long-term effects of stress and glucocorticoid administration on behavioral outcomes, as well as increased blood pressure, altered hypothalamic pituitary adrenal axis (HPA) function, and decreased glucose tolerance and brain size. In humans, licorice, which inhibits placental 11β-HSD2 when consumed during pregnancy, has been shown to increase the risk of behavioral problems linked to altered HPA activity. Synthetic glucocorticoids administered during pregnancy to improve fetal lung maturity in threatened preterm birth have been shown to reduce birth weight and head circumference, but have not been linked to grosschanges in long-term health todate. It is important to consider thelong-term consequences of stress, and medication that mimics stress, during pregnancy. Birth Defects Research (PartC) 96:315–324, 2012. © 2013 Wiley Periodicals, Inc.