Funding: Other than the usual support provided to authors by their institutions, no additional funding was provided to conduct this review.
Article first published online: 21 OCT 2011
Copyright © 2011 Wiley Periodicals, Inc.
Volume 33, Issue 3, pages 187–206, April 2012
How to Cite
Repacholi, M. H., Lerchl, A., Röösli, M., Sienkiewicz, Z., Auvinen, A., Breckenkamp, J., d'Inzeo, G., Elliott, P., Frei, P., Heinrich, S., Lagroye, I., Lahkola, A., McCormick, D. L., Thomas, S. and Vecchia, P. (2012), Systematic review of wireless phone use and brain cancer and other head tumors. Bioelectromagnetics, 33: 187–206. doi: 10.1002/bem.20716
Conflicts of interest: PE and AA are Principal Investigators (PI) of the international COSMOS Study, which is a prospective cohort study investigating the possible long-term health effects of wireless phone use. PE receives funding from the UK Mobile Telecommunications and Health Research (MTHR) Programme (www.mthr.org.uk), an independent body set up to provide funding for research into the possible health effects of mobile telecommunications. MTHR is jointly funded by the UK Department of Health and the mobile telecommunications industry. PE's research is also supported by the Imperial College Healthcare NHS Trust Comprehensive Biomedical Research Centre, funded by the National Institute for Health Research (NIHR) and he is an NIHR Senior Investigator. AA receives research funding for the Finnish COSMOS component from the research programme of the National Technology Agency with contributions from network operators (TeliaSonera and Elisa) and Nokia. AA was the PI of the Finnish component of the Interphone consortium that was funded through the Fifth EU Framework programme, with partial funding from the Mobile Manufacturers Forum and the GSM Association (with UICC as the firewall). All other authors reported no conflicts of interest.
- Issue published online: 2 MAR 2012
- Article first published online: 21 OCT 2011
- Manuscript Accepted: 25 SEP 2011
- Manuscript Received: 11 JAN 2011
- wireless phones;
- brain cancer;
- head tumors;
- radiofrequency fields;
- systematic review
We conducted a systematic review of scientific studies to evaluate whether the use of wireless phones is linked to an increased incidence of the brain cancer glioma or other tumors of the head (meningioma, acoustic neuroma, and parotid gland), originating in the areas of the head that most absorb radiofrequency (RF) energy from wireless phones. Epidemiology and in vivo studies were evaluated according to an agreed protocol; quality criteria were used to evaluate the studies for narrative synthesis but not for meta-analyses or pooling of results. The epidemiology study results were heterogeneous, with sparse data on long-term use (≥10 years). Meta-analyses of the epidemiology studies showed no statistically significant increase in risk (defined as P < 0.05) for adult brain cancer or other head tumors from wireless phone use. Analyses of the in vivo oncogenicity, tumor promotion, and genotoxicity studies also showed no statistically significant relationship between exposure to RF fields and genotoxic damage to brain cells, or the incidence of brain cancers or other tumors of the head. Assessment of the review results using the Hill criteria did not support a causal relationship between wireless phone use and the incidence of adult cancers in the areas of the head that most absorb RF energy from the use of wireless phones. There are insufficient data to make any determinations about longer-term use (≥10 years). Bioelectromagnetics 33:187–206, 2012. © 2011 Wiley Periodicals, Inc.