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ELF magnetic fields tuned to ion parametric resonance conditions do not affect TEA-sensitive voltage-dependent outward K+ currents in a human neural cell line

Authors

  • Entelë Gavoçi,

    1. Department of Physics and Astronomy, University of Bologna, Bologna, Italy
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  • Isabella Zironi,

    1. Department of Physics and Astronomy, University of Bologna, Bologna, Italy
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  • Daniel Remondini,

    1. Department of Physics and Astronomy, University of Bologna, Bologna, Italy
    2. Interdepartmental Center “L. Galvani”, University of Bologna, Bologna, Italy
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  • Angela Virelli,

    1. Department of Physics and Astronomy, University of Bologna, Bologna, Italy
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  • Gastone Castellani,

    1. Department of Physics and Astronomy, University of Bologna, Bologna, Italy
    2. Interdepartmental Center “L. Galvani”, University of Bologna, Bologna, Italy
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  • Brunella Del Re,

    1. Interdepartmental Center “L. Galvani”, University of Bologna, Bologna, Italy
    2. Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy
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  • Gianfranco Giorgi,

    1. Interdepartmental Center “L. Galvani”, University of Bologna, Bologna, Italy
    2. Department of Biology, Geology, and Environmental Sciences, University of Bologna, Bologna, Italy
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  • Giorgio Aicardi,

    1. Interdepartmental Center “L. Galvani”, University of Bologna, Bologna, Italy
    2. Department for Life Quality Studies, University of Bologna, Bologna, Italy
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  • Ferdinando Bersani

    Corresponding author
    1. Department of Physics and Astronomy, University of Bologna, Bologna, Italy
    2. Interdepartmental Center “L. Galvani”, University of Bologna, Bologna, Italy
    • Correspondence to: Ferdinando Bersani, Dipartimento di Fisica, Viale Berti Pichat, 6/2, 40127 Bologna, Italy.

      E-mail: ferdinando.bersani@unibo.it

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  • Entelë Gavoçi and Isabella Zironi contributed equally to this work.

Abstract

Despite the experimental evidence of significant biological effects of extremely low frequency (ELF) magnetic fields (MFs), the underlying mechanisms are still unclear. Among the few mechanisms proposed, of particular interest is the so called “ion parametric resonance (IPR)” hypothesis, frequently referred to as theoretical support for medical applications. We studied the effect of different combinations of static (DC) and alternating (AC) ELF MFs tuned on resonance conditions for potassium (K+) on TEA-sensitive voltage-dependent outward K+ currents in the human neuroblastoma BE(2)C cell line. Currents through the cell membrane were measured by whole-cell patch clamp before, during, and after exposure to MF. No significant changes in K+ current density were found. This study does not confirm the IPR hypothesis at the level of TEA-sensitive voltage-dependent outward K+ currents in our experimental conditions. However, this is not a direct disprove of the hypothesis, which should be investigated on other ion channels and at single channel levels also. Bioelectromagnetics 34:579–588, 2013. © 2013 Wiley Periodicals, Inc.

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