This article was published online on 6 November 2013. Subsequently, a formatting error was found in Table 1, and the correction was published on 10 December 2013.
Mobile phone use and risk of intracranial tumors: A consistency analysis
Version of Record online: 6 NOV 2013
© 2013 Wiley Periodicals, Inc.
Volume 35, Issue 2, pages 79–90, February 2014
How to Cite
Lagorio, S. and Röösli, M. (2014), Mobile phone use and risk of intracranial tumors: A consistency analysis. Bioelectromagnetics, 35: 79–90. doi: 10.1002/bem.21829
- Issue online: 9 JAN 2014
- Version of Record online: 6 NOV 2013
- Manuscript Accepted: 9 OCT 2013
- Manuscript Received: 25 FEB 2013
- radiofrequency fields;
A meta-analysis of studies on intracranial tumors and mobile phone use published by the end of 2012 was performed to evaluate the overall consistency of findings, assess the sensitivity of results to changes in the dataset, and try to detect the sources of between-study heterogeneity. Twenty-nine papers met our inclusion criteria. These papers reported on 47 eligible studies (17 on glioma, 15 on meningioma, 15 on acoustic neuroma), consisting of either primary investigations or pooled analyses. Five combinations of non-overlapping studies per outcome were identified. The combined relative risks (cRRs) in long-term mobile phone users (≥10 years) ranged between 0.98 (0.75–1.28) and 1.11 (0.86–1.44) for meningioma, with little heterogeneity across studies. High heterogeneity was detected across estimates of glioma and acoustic neuroma risk in long term users, with cRRs ranging between 1.19 (95% CI 0.86–1.64) and 1.40 (0.96–2.04), and from 1.14 (0.65–1.99) to 1.33 (0.65–2.73), respectively. A meta-regression of primary studies showed that the methodological differences embedded in the variable “study-group” explained most of the overall heterogeneity in results. Summary risk estimates based on heterogeneous findings should not be over-interpreted. Overall, the results of our study detract from the hypothesis that mobile phone use affects the occurrence of intracranial tumors. However, reproducibility (or lack of) is just one clue in the critical appraisal of epidemiological evidence. Based on other considerations, such as the limited knowledge currently available on risk beyond 15 years from first exposure, or following mobile phone use started in childhood, the pursuance of epidemiological surveillance is warranted. Bioelectromagnetics. 35:79–90, 2014. © 2013 Wiley Periodicals, Inc.