What the papers say
Bacterial actins? An evolutionary perspective
Article first published online: 29 MAR 2002
Copyright © 2002 Wiley Periodicals, Inc.
Volume 24, Issue 4, pages 293–296, April 2002
How to Cite
Doolittle, R. F. and York, A. L. (2002), Bacterial actins? An evolutionary perspective. Bioessays, 24: 293–296. doi: 10.1002/bies.10079
- Issue published online: 29 MAR 2002
- Article first published online: 29 MAR 2002
According to the conventional wisdom, the existence of a cytoskeleton in eukaryotes and its absence in prokaryotes constitute a fundamental divide between the two domains of life. An integral part of the dogma is that a cytoskeleton enabled an early eukaryote to feed upon prokaryotes, a consequence of which was the occasional endosymbiosis and the eventual evolution of organelles. Two recent papers1, 2 present compelling evidence that actin, one of the principal components of a cytoskeleton, has a homolog in Bacteria that behaves in many ways like eukaryotic actin. Sequence comparisons reveal that eukaryotic actin and the bacterialhomolog (mreB protein), unlike many other proteins common to eukaryotes and Bacteria, have very different and more highly extended evolutionary histories. BioEssays 24:293–296, 2002. ©2002 Wiley Periodicals, Inc.