What the papers say
Increasingly complex: New players enter the Wnt signaling network
Article first published online: 25 SEP 2002
Copyright © 2002 Wiley Periodicals, Inc.
Volume 24, Issue 10, pages 881–884, October 2002
How to Cite
Pandur, P., Maurus, D. and Kühl, M. (2002), Increasingly complex: New players enter the Wnt signaling network. Bioessays, 24: 881–884. doi: 10.1002/bies.10164
- Issue published online: 25 SEP 2002
- Article first published online: 25 SEP 2002
Wnt proteins can activate different intracellular signaling cascades in various organisms by interacting with receptors of the Frizzled family. The first identified Wnt signaling pathway, the Wnt/β-catenin pathway, has been studied in much detail and is highly conserved among species. As to non-canonical Wnt pathways, the current situation is more nebulous partly because the intracellular mediators of this pathway are not yet fully understood and, in some cases, even identified. However, there are increasing data that prove the existence of non-canonical Wnt signaling and demonstrate its involvement in different developmental processes. In vertebrates, Wnt-11 and Wnt-5A can activate the Wnt/JNK pathway, which resembles the planar cell polarity pathway in Drosophila. The Wnt/Ca2+-pathway has only been described in Xenopus and zebrafish so far and it is unclear whether it also exists in other organisms. Two recent papers provide us with new insight into non-canonical Wnt signaling by (1) presenting a new intracellular mediator of non-canonical signaling in Xenopus1 and (2) implicating the existence of an additional non-canonical Wnt signaling pathway in flies.2 BioEssays 24:881–884, 2002. © 2002 Wiley Periodicals, Inc.