The viral control of cellular acetylation signaling

Authors

  • Cécile Caron,

    1. Laboratoire de Biologie Moléculaire et Cellulaire de la Différenciation—Equipe chromatine et expression des gènes, Institut Albert Bonniot, France
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  • Edwige Col,

    1. Laboratoire de Biologie Moléculaire et Cellulaire de la Différenciation—Equipe chromatine et expression des gènes, Institut Albert Bonniot, France
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  • Saadi Khochbin

    Corresponding author
    1. Laboratoire de Biologie Moléculaire et Cellulaire de la Différenciation—Equipe chromatine et expression des gènes, Institut Albert Bonniot, France
    • Laboratoire de Biologie Moléculaire et Cellulaire de la Différenciation, INSERM U309, Equipe chromatine et expression des gènes, Institut Albert Bonniot, Faculté de Médecine, Domaine de la Merci, 38706 La Tronche Cedex, France.
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Abstract

It is becoming clear that the post-translational modification of histone and non-histone proteins by acetylation is part of an important cellular signaling process controling a wide variety of functions in both the nucleus and the cytoplasm. Recent investigations designate this signaling pathway as one of the primary targets of viral proteins after infection. Indeed, specific viral proteins have acquired the capacity to interact with cellular acetyltransferases (HATs) and deacetylases (HDACs) and consequently to disrupt normal acetylation signaling pathways, thereby affecting viral and cellular gene expression. Here we review the targeting of cellular HATs and HDACs by viral proteins and highlight different strategies adopted by viruses to control cellular acetylation signaling and to accomplish their life cycle. BioEssays 25:58–65, 2003. © 2002 Wiley Periodicals, Inc.

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