A phylogenetic hypothesis for the origin of hiccough

Authors

  • C. Straus,

    Corresponding author
    1. Respiratory Research Group, Department of Medical Physiology Faculty of Medicine, University of Calgary, Alberta, Canada
    2. UPRES EA 2397, Faculté de Médecine Pitié-Salpêtrière, Université Paris, VI, France
    3. Service Central d'Explorations Fonctionnelles Respiratoires, Groupe Hospitalier Pitie-Salpetriere, Assistance Publique-Hôpitaux de Paris, Paris, France
    • Explorations Fonctionnelles Respiratoires, Groupe Hospitalier Pitié-Salpêtrère, 47-83, Boulevard de l'Hôpital, 75651 Paris Cedex 13, France.
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  • K. Vasilakos,

    1. Respiratory Research Group, Department of Medical Physiology Faculty of Medicine, University of Calgary, Alberta, Canada
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  • R. J. A. Wilson,

    1. Respiratory Research Group, Department of Medical Physiology Faculty of Medicine, University of Calgary, Alberta, Canada
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  • T. Oshima,

    1. Respiratory Research Group, Department of Medical Physiology Faculty of Medicine, University of Calgary, Alberta, Canada
    2. Department of Anesthesiology, Gifu University School of Medicine, Gifu-City, Japan
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  • M. Zelter,

    1. UPRES EA 2397, Faculté de Médecine Pitié-Salpêtrière, Université Paris, VI, France
    2. Service Central d'Explorations Fonctionnelles Respiratoires, Groupe Hospitalier Pitie-Salpetriere, Assistance Publique-Hôpitaux de Paris, Paris, France
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  • J-Ph. Derenne,

    1. UPRES EA 2397, Faculté de Médecine Pitié-Salpêtrière, Université Paris, VI, France
    2. Service de Pneumologie, Groupe Hospitalier Pitie-Salpetriere, Assistance Publique-Hôpitaux de Paris, Paris, France
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  • T. Similowski,

    1. UPRES EA 2397, Faculté de Médecine Pitié-Salpêtrière, Université Paris, VI, France
    2. Service de Pneumologie, Groupe Hospitalier Pitie-Salpetriere, Assistance Publique-Hôpitaux de Paris, Paris, France
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  • W. A. Whitelaw

    1. Respiratory Research Group, Department of Medical Physiology Faculty of Medicine, University of Calgary, Alberta, Canada
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Abstract

The occurrence of hiccoughs (hiccups) is very widespread and yet their neuronal origin and physiological significance are still unresolved. Several hypotheses have been proposed. Here we consider a phylogenetic perspective, starting from the concept that the ventilatory central pattern generator of lower vertebrates provides the base upon which central pattern generators of higher vertebrates develop. Hiccoughs are characterized by glottal closure during inspiration and by early development in relation to lung ventilation. They are inhibited when the concentration of inhaled CO2 is increased and they can be abolished by the drug baclofen (an agonist of the GABAB receptor). These properties are shared by ventilatory motor patterns of lower vertebrates, leading to the hypothesis that hiccough is the expression of archaic motor patterns and particularly the motor pattern of gill ventilation in bimodal breathers such as most frogs. A circuit that can generate hiccoughs may persist in mammals because it has permitted the development of pattern generators for other useful functions of the pharynx and chest wall muscles, such as suckling or eupneic breathing. BioEssays 25:182–188, 2003. © 2003 Wiley Periodicals, Inc.

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