What the papers say
Cancer therapy: switching off oncogenes
Version of Record online: 21 JAN 2003
Copyright © 2003 Wiley Periodicals, Inc.
Volume 25, Issue 2, pages 104–107, February 2003
How to Cite
Pompetti, F., Pilla, D. and Giancola, R. (2003), Cancer therapy: switching off oncogenes. Bioessays, 25: 104–107. doi: 10.1002/bies.10238
- Issue online: 21 JAN 2003
- Version of Record online: 21 JAN 2003
Cancer derives from a cell clone that has accumulated genetic and epigenetic changes that influence its phenotype and finally enable it to escape from the normal controls of proliferation. A recent paper shows that, in myc-induced tumours, the inactivation of this oncogene produces the regression of the tumours and the differentiation of the tumour cells into mature osteocytes.1 In addition, a further reactivation of myc in these cells does not restore the malignant phenotype but induces apoptosis. This discovery could lead to an innovative therapeutic strategy. BioEssays 25:104–107, 2003. © 2003 Wiley Periodicals, Inc.