Neurofilaments and neurological disease
Article first published online: 19 MAR 2003
Copyright © 2003 Wiley Periodicals, Inc.
Volume 25, Issue 4, pages 346–355, April 2003
How to Cite
Al-Chalabi, A. and Miller, C. C. J. (2003), Neurofilaments and neurological disease. Bioessays, 25: 346–355. doi: 10.1002/bies.10251
- Issue published online: 19 MAR 2003
- Article first published online: 19 MAR 2003
Neurofilaments are one of the major components of the neuronal cytoskeleton and are responsible for maintaining the calibre of axons. They are modified by post-translational changes that are regulated in complex fashions including by the interaction with neighbouring glial cells. Neurofilament accumulations are seen in several neurological diseases and neurofilament mutations have now been associated with Charcot-Marie-Tooth disease, Parkinson's disease and amyotrophic lateral sclerosis. In this review, we discuss the structure, normal function and molecular pathology of neurofilaments. BioEssays 25:346–355, 2003. © 2003 Wiley Periodicals, Inc.