Evolving questions and paradigm shifts in endoplasmic-reticulum-associated degradation (ERAD)
Article first published online: 18 AUG 2003
Copyright © 2003 Wiley Periodicals, Inc.
Volume 25, Issue 9, pages 868–877, September 2003
How to Cite
McCracken, A. A. and Brodsky, J. L. (2003), Evolving questions and paradigm shifts in endoplasmic-reticulum-associated degradation (ERAD). Bioessays, 25: 868–877. doi: 10.1002/bies.10320
- Issue published online: 18 AUG 2003
- Article first published online: 18 AUG 2003
- The National Science Foundation
ER-associated degradation (ERAD) is a component of the protein quality control system, ensuring that aberrant polypeptides cannot transit through the secretory pathway. This is accomplished by a complex sequence of events in which unwanted proteins are selected in the ER and exported to the cytosol for degradation by the proteasome. Given that protein quality control can be essential for cell survival, it is not surprising that ERAD is linked to numerous disease states. Here we review the molecular mechanisms of ERAD, its role in metabolic regulation and biomedical implications, and the unanswered questions regarding this process. BioEssays 25:868–877, 2003. © 2003 Wiley Periodicals, Inc.