Shaping the metaphase chromosome: coordination of cohesion and condensation
Article first published online: 25 SEP 2001
Copyright © 2001 John Wiley & Sons, Inc.
Volume 23, Issue 10, pages 924–935, October 2001
How to Cite
Losada, A. and Hirano, T. (2001), Shaping the metaphase chromosome: coordination of cohesion and condensation. Bioessays, 23: 924–935. doi: 10.1002/bies.1133
- Issue published online: 25 SEP 2001
- Article first published online: 25 SEP 2001
- the Human Frontier Science Program. A. L. is supported by a fellowship from the Robertson Research Fund
Recent progress in our understanding of mitotic chromosome dynamics has been accelerated by the identification of two essential protein complexes, cohesin and condensin. Cohesin is required for holding sister chromatids (duplicated chromosomes) together from S phase until the metaphase-to-anaphase transition. Condensin is a central player in chromosome condensation, a process that initiates at the onset of mitosis. The main focus of this review is to discuss how the mitotic metaphase chromosome is assembled and shaped by a precise balance between the cohesion and condensation machineries. We argue that, in different eukaryotic organisms, the balance of cohesion and condensation is adjusted in such a way that the size and shape of the resulting chromosomes are best suited for their accurate segregation. BioEssays 23:924–935, 2001. © 2001 John Wiley & Sons, Inc.