Both authors contributed equally to this work.
The PARP superfamily†
Article first published online: 19 JUL 2004
Copyright © 2004 Wiley Periodicals, Inc.
Volume 26, Issue 8, pages 882–893, August 2004
How to Cite
Amé, J.-C., Spenlehauer, C. and de Murcia, G. (2004), The PARP superfamily. Bioessays, 26: 882–893. doi: 10.1002/bies.20085
- Issue published online: 19 JUL 2004
- Article first published online: 19 JUL 2004
- Centre National de la Recherche Scientifique, Association pour la Recherche Contre le Cancer, Électricité de France, Ligue Nationale Contre le Cancer and Commissariat à l'Énergie Atomique
Poly(ADP-ribosyl)ation is an immediate DNA-damage-dependent post-translational modification of histones and other nuclear proteins that contributes to the survival of injured proliferating cells. Poly(ADP-ribose) polymerases (PARPs) now constitute a large family of 18 proteins, encoded by different genes and displaying a conserved catalytic domain in which PARP-1 (113 kDa), the founding member, and PARP-2 (62 kDa) are so far the sole enzymes whose catalytic activity has been shown to be immediately stimulated by DNA strand breaks. A large repertoire of sequences encoding novel PARPs now extends considerably the field of poly(ADP-ribosyl)ation reactions to various aspects of the cell biology including cell proliferation and cell death. Some of these new members interact with each other, share common partners and common subcellular localizations suggesting possible fine tuning in the regulation of this post-translational modification of proteins. This review summarizes our present knowledge of this emerging superfamily, which might ultimately improve pharmacological strategies to enhance both antitumor efficacy and the treatment of a number of inflammatory and neurodegenerative disorders. A provisional nomenclature is proposed. BioEssays 26:882–893, 2004. © 2004 Wiley Periodicals, Inc.