Iron metabolism: microbes, mouse, and man
Article first published online: 29 OCT 2009
Copyright © 2009 Wiley Periodicals, Inc.
Volume 31, Issue 12, pages 1309–1317, December 2009
How to Cite
Latunde-Dada, G. O. (2009), Iron metabolism: microbes, mouse, and man. Bioessays, 31: 1309–1317. doi: 10.1002/bies.200900101
- Issue published online: 17 NOV 2009
- Article first published online: 29 OCT 2009
Recent advances in research on iron metabolism have revealed the identity of a number of genes, signal transduction pathways, and proteins involved in iron regulation in mammals. The emerging paradigm is a coordination of homeostasis within a network of classical iron metabolic pathways and other cellular processes such as cell differentiation, growth, inflammation, immunity, and a host of physiologic and pathologic conditions. Iron, immunity, and infection are intricately linked and their regulation is fundamental to the survival of mammals. The mutual dependence on iron by the host and invading pathogenic organisms elicits competition for the element during infection. While the host maintains mechanisms to utilize iron for its own metabolism exclusively, pathogenic organisms are armed with a myriad of strategies to circumvent these measures. This review explores iron metabolism in mammalian host, defense mechanisms against pathogenic microbes and the competitive devices of microbes for access to iron.