Thalidomide-induced limb defects: resolving a 50-year-old puzzle
Article first published online: 17 NOV 2009
Copyright © 2009 Wiley Periodicals, Inc.
Volume 31, Issue 12, pages 1327–1336, December 2009
How to Cite
Vargesson, N. (2009), Thalidomide-induced limb defects: resolving a 50-year-old puzzle. Bioessays, 31: 1327–1336. doi: 10.1002/bies.200900103
- Issue published online: 17 NOV 2009
- Article first published online: 17 NOV 2009
- chick limb development;
- thalidomide analogue;
Despite the recent discovery that thalidomide causes limb defects by targeting highly angiogenic, immature blood vessels, several challenges still remain and new ones have arisen. These include understanding the drug's species specificity, determining molecular target(s) in the endothelial cell, shedding light on the molecular basis of phocomelia and producing a form of the drug that is clinically effective without having side effects. Now that the trigger of thalidomide-induced teratogenesis has been uncovered, a framework is proposed, incorporating and uniting previous models of thalidomide action, explaining how thalidomide causes not just limb defects, but also all the other defects it induces.