Imaginal discs: Renaissance of a model for regenerative biology

Authors

  • Cora Bergantiños,

    1. Facultat de Biologia, Departament de Genètica, Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, Barcelona, Spain
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  • Xavier Vilana,

    1. Facultat de Biologia, Departament de Genètica, Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, Barcelona, Spain
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  • Montserrat Corominas,

    1. Facultat de Biologia, Departament de Genètica, Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, Barcelona, Spain
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  • Florenci Serras

    Corresponding author
    1. Facultat de Biologia, Departament de Genètica, Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, Barcelona, Spain
    • Facultat de Biologia, Departament de Genètica, Universitat de Barcelona, Av. Diagonal 645, 08028 Barcelona, Spain.
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Abstract

Many animals display a capacity to regenerate tissues or even a complete body. One of the main goals of regenerative biology is to identify the genes and genetic networks necessary for this process. Drosophila offers an ideal model system for such studies. The wide range of genetic and genomic approaches available for use in flies has helped in initiating the deciphering of the mechanisms underlying regeneration, and the results may be applicable to other organisms, including mammals. Moreover, most models of regeneration require experimental manipulation, whereas in Drosophila discrete domains can be ablated by genetically induced methods. Here, we present a summary of current research into imaginal disc regeneration and discuss the power of this tissue as a tool for understanding the genetics of regeneration.

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