Eukaryotic cold shock domain proteins: highly versatile regulators of gene expression
Article first published online: 20 JAN 2010
Copyright © 2010 Wiley Periodicals, Inc.
Volume 32, Issue 2, pages 109–118, February 2010
How to Cite
Mihailovich, M., Militti, C., Gabaldón, T. and Gebauer, F. (2010), Eukaryotic cold shock domain proteins: highly versatile regulators of gene expression. Bioessays, 32: 109–118. doi: 10.1002/bies.200900122
- Issue published online: 20 JAN 2010
- Article first published online: 20 JAN 2010
- Spanish Ministry of Education and Science. Grant Number: BFU2006-01874
- translation initiation factor;
Cold shock domain (CSD)-containing proteins have been found in all three domains of life and function in a variety of processes that are related, for the most part, to post-transcriptional gene regulation. The CSD is an ancient β-barrel fold that serves to bind nucleic acids. The CSD is structurally and functionally similar to the S1 domain, a fold with otherwise unrelated primary sequence. The flexibility of the CSD/S1 domain for RNA recognition confers an enormous functional versatility to the proteins that contain them. This review summarizes the current knowledge on eukaryotic CSD/S1 domain-containing proteins with a special emphasis on UNR (upstream of N-ras), a member of this family with multiple copies of the CSD.